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Reversal of Vascular and Renal Crises of Scleroderma by Oral Angiotensin-Converting-Enzyme Blockade
Abstract
UNTIL successful medical management of scleroderma crisis was reported,1 2 3 4 bilateral nephrectomy was thought to be the only therapy to control this emergency and permit survival.5 6 7 We report here two cases of dramatic reversal of scleroderma vascular and renal crises with the oral angiotensin-converting-enzyme inhibitor SQ 14225 (Captopril).8 , 9 Case Reports Case 1. Scleroderma was diagnosed in a 33-year-old woman in 1976. In 1977, a hospital evaluation revealed that her blood pressure was 120/80 mm Hg, serum creatinine 0.8 mg per 100 ml, creatinine clearance 86 ml per minute, urinary protein less than 100 mg per 24 hours, plasma renin activity 2.0 . . .
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Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209909 · Cited by 1,104
Steen, V. D., Costantino, J. P., Shapiro, A. P., & Medsger, T. A. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-5-352 · Cited by 441
Metadata
- Authors
- Lopez-Ovejero, J. A., Saal, S. D., D'Angelo, W. A., Cheigh, J. S., Stenzel, K. H., & Laragh, J. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-06-21
- Volume
- 300
- Issue
- 25
- Pages
- 1417-1419
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2086506381
- Cited by
- 207
- References
- 0
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reversal of Vascular and Renal Crises of Scleroderma by Oral Angiotensin-Converting-Enzyme Blockade. https://app.cochat.ai/papers/10.1056/nejm197906213002505
- The paper
- Lopez-Ovejero, J. A., Saal, S. D., D'Angelo, W. A., Cheigh, J. S., Stenzel, K. H., & Laragh, J. H. (1979). Reversal of Vascular and Renal Crises of Scleroderma by Oral Angiotensin-Converting-Enzyme Blockade. New England Journal of Medicine. https://doi.org/10.1056/nejm197906213002505
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
