Gastrointestinal-motility dysfunction in amyloidosis
Abstract
SYSTEMIC amyloidosis frequently involves the gastrointestinal tract and may result in obstruction, malabsorption, ulceration, hemorrhage or perforation as well as impaired motility.1 2 3 It is unclear whether the impaired gastrointestinal motility is secondary to the effects of amyloid on the smooth muscle or on the autonomic nervous system. We report on a patient with primary amyloidosis, in whom esophageal manometric and colonic myoelectric studies revealed a widespread disorder of gastrointestinal motility. The evidence suggests that neural dysfunction contributes to the abnormal motility associated with amyloidosis.Case ReportA 68-year-old woman was admitted to the Hospital of the University of Pennsylvania with . . .
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Later stages of amyloidosis may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Battle et al., 1979
Manometric studies suggest that early amyloidosis can manifest with motor incoordination consistent with neural involvement.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Battle et al., 1979
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References 10 · Cited by 110
- Authors
- Battle, W. M., Rubin, M. R., Cohen, S., & Snape, W. J.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- ORCID
- Cohen, Sidney
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-07-05
- Volume
- 301
- Issue
- 1
- Pages
- 24-25
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2079783462
- Cited by
- 110
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Keywords
- systemic amyloidosis, AL amyloidosis, gastrointestinal motility disorders, esophageal manometry, autonomic dysfunction, smooth muscle dysfunction, esophageal motility disorders, colonic motility disorders
- MeSH terms
- Aged, Amyloidosis, Colon, Esophagogastric Junction, Esophagus, Female, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Manometry, Muscle, Smooth, Neostigmine, Nervous System Diseases, Neural Pathways, Peripheral Nervous System Diseases, Peristalsis, Pressure
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