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The Chemotherapy of Plasma-Cell Myeloma and the Incidence of Acute Leukemia
Abstract
Previously untreated patients with myeloma were randomized to initial treatment with melphalan and prednisone (and to cyclophosphamide or carmustine if relapse or progression occurred)(Group A, 125 patients), melphalan, cyclophosphamide, carmustine and prednisone in alternating (Group B, 123 patients) or concurrent (Group C, 116 patients) schedules. The groups were similar with respect to known prognostic factors. Response rates and survival were also similar. We were unable to identify a subgroup of patients who responded or survived better on melphalan-cyclophosphamide-carmustine and prednisone than on melphalan and prednisone. We conclude that the combination of the four drugs is not better than melphalen and prednisone for inducing responses or prolonging the survival of patients with myeloma. Myelomas producing only gamma chains have a poorer prognosis (P greater than 0.001) than IgG, IgA, or kappa myeloma. Acute leukemia has developed in 14 patients. The actuarial risk of developing acute leukemia, has increased rapidly to 17.4 per cent at 50 months.
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Cited by
BladÉ, J., Samson, D., Reece, D., Apperley, J., BJÖrkstrand, B., Gahrton, G., Gertz, M., Giralt, S., Jagannath, S., Vesole, D., et al. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00930.x · Cited by 1,519
Publication bias: the case for an international registry of clinical trials.
Simes, R. J. (1986) · Journal of Clinical Oncology · doi:10.1200/jco.1986.4.10.1529 · Cited by 747
Rowley, J., Golomb, H., & Vardiman, J. (1981) · Blood · doi:10.1182/blood.v58.4.759.759 · Cited by 441
San Miguel, J. F., Schlag, R., Khuageva, N. K., Dimopoulos, M. A., Shpilberg, O., Kropff, M., Spicka, I., Petrucci, M. T., Palumbo, A., Samoilova, O. S., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.6180 · Cited by 265
The application and biology of immunomodulatory drugs (IMiDs) in cancer
Pan, B., & Lentzsch, S. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.07.004 · Cited by 76
Metadata
- Authors
- Bergsagel, D. E., Bailey, A. J., Langley, G. R., MacDonald, R. N., White, D. F., & Miller, A. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-10-04
- Volume
- 301
- Issue
- 14
- Pages
- 743-748
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2059403857
- Cited by
- 376
- References
- 0
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bergsagel, D. E., Bailey, A. J., Langley, G. R., MacDonald, R. N., White, D. F., & Miller, A. B. (1979). The Chemotherapy of Plasma-Cell Myeloma and the Incidence of Acute Leukemia. New England Journal of Medicine. https://doi.org/10.1056/nejm197910043011402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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