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Effect of Cholesterol on Production of Thromboxane B2by Platelets in Vitro
Abstract
We altered platelet cholesterol by incubating the cells with either "cholesterol-rich" or "cholesterol-poor" liposomes. These platelets were then used to study the influence of cholesterol content on the metabolism of arachidonic acid, a fatty acid that serves as the critical precursor in the platelet for formation of the potent aggregating agent thromboxane A2. After addition of the aggregating agent thrombin, cholesterol-enriched platelets released 18.1 +/- 0.6 per cent (mean +/- 1 S.E.M.) [14C]arachidonic acid from prelabeled platelet phospholipids. This value was higher (P less than 0.001) than that for cholesterol-depleted platelets (14.6 +/- 1.0 per cent). Conversion of released arachidonic acid to platelet thromboxane B2 (the stable end product of thromboxane A2) was also higher in cholesterol-rich platelets (22.6 +/- 3.9 per cent) than in cholesterol-depleted platelets (13.8 +/- 2.7 per cent). These studies show that changes in the cholesterol content of human platelets in vitro have a significant effect on platelt metabolism of arachidonic acid. N Engl J Med 302:6-10, 1980).
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Citations
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Eaton, S. B., Konner, M., & Shostak, M. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90113-1 · Cited by 703
Hirsh, P. D., Hillis, L. D., Campbell, W. B., Firth, B. G., & Willerson, J. T. (1981) · New England Journal of Medicine · doi:10.1056/nejm198103193041201 · Cited by 594
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Podrez, E. A., Byzova, T. V., Febbraio, M., Salomon, R. G., Ma, Y., Valiyaveettil, M., Poliakov, E., Sun, M., Finton, P. J., Curtis, B. R., et al. (2007) · Nature Medicine · doi:10.1038/nm1626 · Cited by 513
Lacoste, L., Lam, J. Y. T., Hung, J., Letchacovski, G., Solymoss, C. B., & Waters, D. (1995) · Circulation · doi:10.1161/01.cir.92.11.3172 · Cited by 441
Metadata
- Authors
- Stuart, M. J., Gerrard, J. M., & White, J. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-01-03
- Volume
- 302
- Issue
- 1
- Pages
- 6-10
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2318504971
- Cited by
- 321
- References
- 0
- FWCI
- 21.99
- Type
- journal article
- Language
- en
- Open access
- closed
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