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Reduction by Cimetidine of Serum Parathyroid Hormone Levels in Uremic Patients
Abstract
Dietary restriction of phosphorus1 , 2 and administration of antacids3 have been shown to prevent or reverse uremic hyperparathyroidism, but patients find this therapy unpalatable and difficult to maintain. Recent case reports suggest a decrease of circulating levels of immunoreactive parathyroid hormone (iPTH) with cimetidine in two patients with primary hyperparathyroidism and ulcer disease.4 , 5 We therefore evaluated the effects of cimetidine on circulating levels of iPTH, ionized calcium, magnesium, and phosphorus in patients on maintenance hemodialysis for end-stage renal disease. We found that cimetidine reversibly lowered iPTH levels without affecting serum concentrations of calcium, phosphorus, or magnesium.MethodsSeven patients (five men . . .
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Cited by
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HARMAN, D. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27444.x · Cited by 262
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Pension, J., & Wormsley, K. G. (1986) · Medical Toxicology · doi:10.1007/bf03259837 · Cited by 63
Metadata
- Authors
- Jacob, A. I., Lanier, D., Canterbury, J., & Bourgoignie, J. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-03-20
- Volume
- 302
- Issue
- 12
- Pages
- 671-674
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2032697327
- Cited by
- 252
- References
- 0
- FWCI
- 34.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduction by Cimetidine of Serum Parathyroid Hormone Levels in Uremic Patients. https://app.cochat.ai/papers/10.1056/nejm198003203021207
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- Jacob, A. I., Lanier, D., Canterbury, J., & Bourgoignie, J. J. (1980). Reduction by Cimetidine of Serum Parathyroid Hormone Levels in Uremic Patients. New England Journal of Medicine. https://doi.org/10.1056/nejm198003203021207
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