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Regulation of the Immune Response — Role of the Macrophage
Abstract
MACROPHAGES facilitate a variety of thymus-dependent immunologic phenomena in human beings and laboratory animals; thus, these cells are essential for the development of cellular and humoral immunocompetence.1 ,1a Their role in T-cell and B-cell function is shown schematically in Figure 1. Macrophages serve at least four distinct but interlocking functions in host defense. First of all, the induction of T-lymphocyte proliferation requires the physical association of the T cells with macrophages bearing antigen.1b Secondly, the macrophage is a principal site of control by the immune-response gene.2 Thirdly, macrophages have several plasma-membrane receptors, such as those for the Fc portion of IgG, that . . .
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Cited by
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Qureshi, M. A., Garlich, J. D., & Kidd, M. T. (1996) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979609052748 · Cited by 172
Metadata
- Authors
- Rosenthal, A. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-11-13
- Volume
- 303
- Issue
- 20
- Pages
- 1153-1156
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1990365050
- Cited by
- 161
- References
- 0
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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