The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Long-Term Digitalis Therapy Improves Left Ventricular Function in Heart Failure
Abstract
To clarify the controversy regarding the benefits of long-term oral digoxin in the treatment of heart failure, we evaluated hemodynamics at rest and during exercise in nine patients in sinus rhythm with symptomatic heart failure. Patients were studied during long-term digoxin therapy, after withdrawal of the drug, and six hours after readministration. Upon withdrawal of digoxin, pulmonary capillary-wedge pressure increased from 21 +/- 8 to 29 +/- 10 mm Hg, and cardiac index decreased from 2.4 +/- 0.7 to 2.1 +/- 0.6 liters per minute per square meter of body-surface area, suggesting a deterioration in left ventricular function. In addition, heart rate tended to increase and stroke-work index, stroke-volume index, and radioangiographic ejection fraction decreased. Acute readministration restored the hemodynamic values to those observed during long-term digoxin therapy. The improvement in hemodynamics during long-term digoxin administration was also observed during exercise. This improvement demonstrated the value of long-term oral digoxin therapy in congestive heart failure.
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Cites
Mason, D. T., Braunwald, E., Karsh, R. B., & Bullock, F. A. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104939 · Cited by 322
Exercise capacity in patients with severe left ventricular dysfunction.
Benge, W., Litchfield, R. L., & Marcus, M. L. (1980) · Circulation · doi:10.1161/01.cir.61.5.955 · Cited by 212
Maintenance digoxin after an episode of heart failure: placebo-controlled trial in outpatients.
Dobbs, S. M., Kenyon, W. I., & Dobbs, R. J. (1977) · BMJ · doi:10.1136/bmj.1.6063.749 · Cited by 178
IS MAINTENANCE DIGOXIN NECESSARY IN PATIENTS WITH SINUS RHYTHM?
Johnston, G., & McDevitt, D. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91002-x · Cited by 146
DISCONTINUATION OF MAINTENANCE DIGOXIN THERAPY IN GENERAL PRACTICE
Hull, S. M., & Mackintosh, A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91886-4 · Cited by 131
Maintenance Digoxin in Elderly Patients
Dall, J. L. C. (1970) · BMJ · doi:10.1136/bmj.2.5711.705 · Cited by 126
Blind study on the action of digitoxin on elderly women
Starr, I., & Luchi, R. J. (1969) · American Heart Journal · doi:10.1016/0002-8703(69)90440-2 · Cited by 71
The Efficacy of Digitalis Withdrawal in an Institutional Aged Population
FONROSE, H. A., AHLBAUM, N., BUGATCH, E., Cohen, M., GENOVESE, C., & Kelly, J. G. (1974) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1974.tb01940.x · Cited by 69
Dose-response relation between therapeutic levels of serum digoxin and systolic time intervals
Hoeschen, R. J., & Cuddy, T. E. (1975) · The American Journal of Cardiology · doi:10.1016/0002-9149(75)90828-0 · Cited by 66
O’Rourke, R. A., Henning, H., Théroux, P., Crawford, M. H., & Ross, J. (1976) · The American Journal of Cardiology · doi:10.1016/0002-9149(76)90364-7 · Cited by 33
Cited by
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8776 · Cited by 2,106
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.013 · Cited by 1,374
Digitalis: Mechanisms of Action and Clinical Use
Epstein, F. H., & Smith, T. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802113180606 · Cited by 346
Metadata
- Authors
- Arnold, S. B., Byrd, R. C., Meister, W., Melmon, K., Cheitlin, M. D., Bristow, J. D., Parmley, W. W., & Chatterjee, K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-12-18
- Volume
- 303
- Issue
- 25
- Pages
- 1443-1448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2312342505
- Cited by
- 299
- References
- 11
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Long-Term Digitalis Therapy Improves Left Ventricular Function in Heart Failure. https://app.cochat.ai/papers/10.1056/nejm198012183032503
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- Arnold, S. B., Byrd, R. C., Meister, W., Melmon, K., Cheitlin, M. D., Bristow, J. D., Parmley, W. W., & Chatterjee, K. (1980). Long-Term Digitalis Therapy Improves Left Ventricular Function in Heart Failure. New England Journal of Medicine. https://doi.org/10.1056/nejm198012183032503
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
