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Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast
Abstract
From 1973 to 1980, we carried out a controlled study at the National Cancer Institute in Milan to consider the value of a conservative procedure in patients with breast cancer of small size. We randomized 701 patients with breast cancer measuring less than 2 cm in diameter and with no palpable axillary lymph nodes to Halsted radical mastectomy or to "quadrantectomy" with axillary dissection and radiotherapy to the ipsilateral residual breast tissue. We treated 349 patients with Halsted mastectomy and 352 with quadrantectomy. The two groups were comparable in age distribution, size and site of primary tumor, menopausal status, and frequency of axillary metastases. There were three local recurrences in the Halsted group and one in the quadrantectomy group. Actuarial curves showed no difference between the two groups in disease-free or overall survival. From these results, mastectomy appears to involve unnecessary mutilation in patients with breast cancer of less than 2 cm and no palpable axillary nodes.
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Cited by
Fisher, B., Anderson, S., Bryant, J., Margolese, R. G., Deutsch, M., Fisher, E. R., Jeong, J.-H., & Wolmark, N. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa022152 · Cited by 6,249
Veronesi, U., Cascinelli, N., Mariani, L., Greco, M., Saccozzi, R., Luini, A., Aguilar, M., & Marubini, E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020989 · Cited by 4,450
Self-citationvan Dongen, J. A. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.14.1143 · Cited by 1,271
Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status
Haffty, B. G., Harrold, E., Khan, A. J., Pathare, P., Smith, T. E., Turner, B. C., Glazer, P. M., Ward, B., Carter, D., Matloff, E., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08434-9 · Cited by 307
Breast Cancer Management: Quality-of-Life and Cost Considerations
Radice, D., & Redaelli, A. (2003) · PharmacoEconomics · doi:10.2165/00019053-200321060-00003 · Cited by 146
Long-Term Psychological Sequelae of Mastectomy and Breast Conserving Treatment for Breast Cancer
Meyer, L., & Aspegren, K. (1989) · Acta Oncologica · doi:10.3109/02841868909111174 · Cited by 120
Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82
A Prospective Study of Psychiatric and Psychosocial Sequelae of Bilateral Subcutaneous Mastectomy
Meyer, L., & Ringberg, A. (1986) · Scandinavian Journal of Plastic and Reconstructive Surgery · doi:10.3109/02844318609006302 · Cited by 27
Metadata
- Authors
- Veronesi, U., Saccozzi, R., Del Vecchio, M., Banfi, A., Clemente, C., De Lena, M., Gallus, G., Greco, M., Luini, A., Marubini, E., Muscolino, G., Rilke, F., Salvadori, B., Zecchini, A., & Zucali, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-07-02
- Volume
- 305
- Issue
- 1
- Pages
- 6-11
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2396940271
- Cited by
- 1,599
- References
- 0
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- closed
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