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Acyclovir Prophylaxis of Herpes-Simplex-Virus Infections: A Randomized, Double-Blind, Controlled Trial in Bone-Marrow-Transplant Recipients
Abstract
We conducted a double-blind, placebo-controlled study of acyclovir prophylaxis against infection with herpes simplex virus (HSV) in 20 seropositive recipients of bone-marrow transplants. Acyclovir or placebo was administered for 18 days, starting three days before transplantation. Culture-positive HSV lesions developed during the study in seven of the 10 patients who received placebo. In contrast, no such lesions appeared in the 10 patients who received acyclovir (P congruent to 0.003). None of the patients had evidence of drug toxicity. Five of the patients treated with acyclovir had mild culture-positive HSV infections after cessation of the drug, and two additional patients shed virus without having lesions. Acyclovir appears to be a potent inhibitor of HSV replication. Although acyclovir does no appear to eradicate latent infection, it can provide effective prophylaxis against reactivated infections.
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Citations
Cited by
Freifeld, A. G., Bow, E. J., Sepkowitz, K. A., Boeckh, M. J., Ito, J. I., Mullen, C. A., Raad, I. I., Rolston, K. V., Young, J.-A. H., & Wingard, J. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir073 · Cited by 3,463
The purine path to chemotherapy
Elion, G. B. (1989) · Science · doi:10.1126/science.2649979 · Cited by 687
Flowers, C. R., Seidenfeld, J., Bow, E. J., Karten, C., Gleason, C., Hawley, D. K., Kuderer, N. M., Langston, A. A., Marr, K. A., Rolston, K. V. I., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.8661 · Cited by 448
Gut microbiota trajectory in pediatric patients undergoing hematopoietic SCT
Biagi, E., Zama, D., Nastasi, C., Consolandi, C., Fiori, J., Rampelli, S., Turroni, S., Centanni, M., Severgnini, M., Peano, C., et al. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.16 · Cited by 158
Metadata
- Authors
- Saral, R., Burns, W. H., Laskin, O. L., Santos, G. W., & Lietman, P. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-07-09
- Volume
- 305
- Issue
- 2
- Pages
- 63-67
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337976486
- Cited by
- 591
- References
- 0
- FWCI
- 68.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acyclovir Prophylaxis of Herpes-Simplex-Virus Infections: A Randomized, Double-Blind, Controlled Trial in Bone-Marrow-Transplant Recipients. https://app.cochat.ai/papers/10.1056/nejm198107093050202
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- Saral, R., Burns, W. H., Laskin, O. L., Santos, G. W., & Lietman, P. S. (1981). Acyclovir Prophylaxis of Herpes-Simplex-Virus Infections: A Randomized, Double-Blind, Controlled Trial in Bone-Marrow-Transplant Recipients. New England Journal of Medicine. https://doi.org/10.1056/nejm198107093050202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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