The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dexamethasone Proves Deleterious in Cerebral Malaria: A Double-Blind Trial in 100 Comatose Patients
Abstract
High-dose dexamethasone was compared with placebo in a double-blind trial involving 100 comatose patients with strictly defined cerebral malaria. The two treatment groups, whose members were six to 70 years old, proved comparable on admission. There were eight deaths in the dexamethasone group and nine in the placebo group (no significant difference; P = 0.8); at post-mortem examination the brain showed features diagnostic of cerebral malaria in all but one patient who died. Dexamethasone prolonged coma among the survivors: the interval between the start of treatment and the full recovery of consciousness was 63.2 +/- 5.9 hours (mean +/- S.E.M.) in the dexamethasone group, as compared with 47.4 +/- 3.2 hours in the placebo group (P = 0.02). Complications, including pneumonia and gastrointestinal bleeding, occurred in 26 patients given dexamethasone and 11 given placebo (P = 0.004). Only five patients had neurologic sequelae. Results were similar in a subgroup of 28 children six to 14 years old. Dexamethasone is deleterious in cerebral malaria and should no longer be used.
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Citations
Cites
ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
Cited by
Tunkel, A. R., Glaser, C. A., Bloch, K. C., Sejvar, J. J., Marra, C. M., Roos, K. L., Hartman, B. J., Kaplan, S. L., Scheld, W. M., & Whitley, R. J. (2008) · Clinical Infectious Diseases · doi:10.1086/589747 · Cited by 1,193
World Health Organization (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90300-6 · Cited by 1,085
CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA
Bartoloni, A., & Zammarchi, L. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.026 · Cited by 304
Bruneel, F., Hocqueloux, L., Alberti, C., Wolff, M., Chevret, S., Bédos, J.-P., Durand, R., Le Bras, J., Régnier, B., & Vachon, F. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-631oc · Cited by 207
Anxiety caused by a short-life hypnotic.
Morgan, K., & Oswald, I. (1982) · BMJ · doi:10.1136/bmj.284.6320.942 · Cited by 137
Metadata
- Authors
- Warrell, D. A., Looareesuwan, S., Warrell, M. J., Kasemsarn, P., Intaraprasert, R., Bunnag, D., & Harinasuta, T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-02-11
- Volume
- 306
- Issue
- 6
- Pages
- 313-319
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2036118178
- Cited by
- 486
- References
- 1
- FWCI
- 38.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dexamethasone Proves Deleterious in Cerebral Malaria: A Double-Blind Trial in 100 Comatose Patients. https://app.cochat.ai/papers/10.1056/nejm198202113060601
- The paper
- Warrell, D. A., Looareesuwan, S., Warrell, M. J., Kasemsarn, P., Intaraprasert, R., Bunnag, D., & Harinasuta, T. (1982). Dexamethasone Proves Deleterious in Cerebral Malaria: A Double-Blind Trial in 100 Comatose Patients. New England Journal of Medicine. https://doi.org/10.1056/nejm198202113060601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
