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A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations: Benefit of Perioperative Dipyridamole and Aspirin Therapy on Early Postoperative Vein-Graft Patency
Abstract
To prevent occlusion of aortocoronary-artery-bypass grafts, we conducted a prospective, randomized-double-blind trial comparing dipyridamole (instituted two days before operation) plus aspirin (added seven hours after operation) with placebo in 407 patients. Vein-graft angiography was performed in 360 patients (88 per cent) within six months of operation (median, eight days). Within one month of operation, 3 per cent of vein-graft distal anastomoses (10 of 351) were occluded in the treated patients, and 10 per cent (38 of 362) in the placebo group; the proportion of patients with one or more distal anastomoses occluded was 8 per cent (10 of 130) in the treated group and 21 per cent (27 of 130) in th placebo group. This benefit in graft patency persisted in each of over 50 subgroups. Early postoperative bleeding was similar in the two groups. In this trial dipyridamole and aspirin were effective in preventing graft occlusion early after operation.
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Cited by
Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh, M. E., Domanski, M., Sleeper, L. A., Siami, F. S., Dangas, G., Mack, M., Yang, M., Cohen, D. J., Rosenberg, Y., Solomon, S. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211585 · Cited by 1,922
Self-citationLevine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.513 · Cited by 1,641
Levine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000404 · Cited by 1,355
Aspirin, Sulfinpyrazone, or Both in Unstable Angina: Results of a Canadian Multicenter Trial
Cairns, J. A., Gent, M., Singer, J., Finnie, K. J., Froggatt, G. M., Holder, D. A., Jablonsky, G., Kostuk, W. J., Melendez, L. J., Myers, M. G., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511283132201 · Cited by 1,120
Metadata
- Authors
- Chesebro, J. H., Clements, I. P., Fuster, V., Elveback, L. R., Smith, H. C., Bardsley, W. T., Frye, R. L., Holmes, D. R., Vlietstra, R. E., Pluth, J. R., Wallace, R. B., Puga, F. J., Orszulak, T. A., Piehler, J. M., Schaff, H. V., & Danielson, G. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-07-08
- Volume
- 307
- Issue
- 2
- Pages
- 73-78
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2328870579
- Cited by
- 537
- References
- 0
- FWCI
- 75.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations: Benefit of Perioperative Dipyridamole and Aspirin Therapy on Early Postoperative Vein-Graft Patency. https://app.cochat.ai/papers/10.1056/nejm198207083070201
- The paper
- Chesebro, J. H., Clements, I. P., Fuster, V., Elveback, L. R., Smith, H. C., Bardsley, W. T., Frye, R. L., Holmes, D. R., Vlietstra, R. E., Pluth, J. R., Wallace, R. B., Puga, F. J., Orszulak, T. A., Piehler, J. M., Schaff, H. V., & Danielson, G. K. (1982). A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations: Benefit of Perioperative Dipyridamole and Aspirin Therapy on Early Postoperative Vein-Graft Patency. New England Journal of Medicine. https://doi.org/10.1056/nejm198207083070201
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
