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Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura
Abstract
A platelet-agglutinating factor has been detected in the plasma of some patients during episodes of thrombotic thrombocytopenic purpura (TTP).1 , 2 Agglutination induced in vitro by this plasma factor is inhibited by normal plasma and does not require platelet production of the arachidonic acid metabolite thromboxane A2, release of granule contents, platelet metabolism, or calcium or magnesium ions.3 These characteristics are similar to those of agglutination induced in vitro by the attachment to platelets of large, multimeric, von Willebrand factor components of the factor VIII complex (VIII:vWF), and this similarity led us in the present study to investigate the properties . . .
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Citations
Cited by
Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura
Tsai, H.-M., & Lian, E. C.-Y. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811263392203 · Cited by 1,760
In vitro microvessels for the study of angiogenesis and thrombosis
Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201240109 · Cited by 894
ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura
Zheng, X. L. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-061813-013241 · Cited by 264
Metadata
- Authors
- Moake, J. L., Rudy, C. K., Troll, J. H., Weinstein, M. J., Colannino, N. M., Azocar, J., Seder, R. H., Hong, S. L., & Deykin, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-12-02
- Volume
- 307
- Issue
- 23
- Pages
- 1432-1435
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2041065426
- Cited by
- 1,105
- References
- 0
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura. https://app.cochat.ai/papers/10.1056/nejm198212023072306
- The paper
- Moake, J. L., Rudy, C. K., Troll, J. H., Weinstein, M. J., Colannino, N. M., Azocar, J., Seder, R. H., Hong, S. L., & Deykin, D. (1982). Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura. New England Journal of Medicine. https://doi.org/10.1056/nejm198212023072306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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