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Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney
Abstract
ACUTE renal failure occasionally complicates therapy with the oral angiotensin-converting-enzyme inhibitor captopril.1 2 3 4 5 A variety of mechanisms have been postulated to account for captopril-induced renal insufficiency, including direct drug nephrotoxicity,1 hypersensitivity,2 and renal ischemia due to rapid reductions in systemic blood pressure.3 However, the clinical importance of these complications and the types of patients at risk have not been defined.We describe 11 patients in whom acute renal insufficiency developed while they were receiving captopril for treatment of severe hypertension associated with either bilateral renal-artery stenosis or renal-artery stenosis in a solitary kidney. In each case, the renal insufficiency resolved promptly . . .
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Citations
Cited by
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Hirsch, A. T., Haskal, Z. J., Hertzer, N. R., Bakal, C. W., Creager, M. A., Halperin, J. L., Hiratzka, L. F., Murphy, W. R. C., Olin, J. W., Puschett, J. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.174526 · Cited by 3,708
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127
Angiotensin-Converting Enzyme Inhibitors
Brown, N. J., & Vaughan, D. E. (1998) · Circulation · doi:10.1161/01.cir.97.14.1411 · Cited by 958
Metadata
- Authors
- Hricik, D. E., Browning, P. J., Kopelman, R., Goorno, W. E., Madias, N. E., & Dzau, V. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-02-17
- Volume
- 308
- Issue
- 7
- Pages
- 373-376
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2086524451
- Cited by
- 653
- References
- 0
- FWCI
- 73.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney. https://app.cochat.ai/papers/10.1056/nejm198302173080706
- The paper
- Hricik, D. E., Browning, P. J., Kopelman, R., Goorno, W. E., Madias, N. E., & Dzau, V. J. (1983). Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney. New England Journal of Medicine. https://doi.org/10.1056/nejm198302173080706
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
