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Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage
Abstract
We enrolled 125 neurologically normal patients with intracranial aneurysms in a multi-institution, prospective, double-blind, randomized, placebo-controlled trial within 96 hours of their subarachnoid hemorrhage, to determine whether treatment with the calcium blocker nimodipine would prevent or reduce the severity of ischemic neurologic deficits from arterial spasm. A deficit from cerebral arterial spasm that persisted and was severe or caused death by the end of the 21-day treatment period occurred in 8 of 60 patients given placebo and in 1 of 56 given nimodipine (P = 0.03, Fisher's exact test). Analysis of the amount of basal subarachnoid blood on pre-entry CAT scans in patients with deficits from spasm showed that an increase in subarachnoid blood was not associated with a worse neurologic outcome among patients who received nimodipine, unlike the situation in patients given a placebo. There were no side effects from nimodipine. We conclude that nimodipine should be given to patients who are neurologically normal after subarachnoid hemorrhage in order to reduce the occurrence of severe neurologic deficits due to cerebral arterial spasm.
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Cited by
Tator, C. H., & Fehlings, M. G. (1991) · Journal of Neurosurgery · doi:10.3171/jns.1991.75.1.0015 · Cited by 1,577
Diringer, M. N., Bleck, T. P., Claude Hemphill, J., Menon, D., Shutter, L., Vespa, P., Bruder, N., Connolly, E. S., Citerio, G., Gress, D., et al. (2011) · Neurocritical Care · doi:10.1007/s12028-011-9605-9 · Cited by 1,121
National Clinical Guidelines for Stroke.
Robinson, T. (2001) · Postgraduate Medical Journal · doi:10.1136/pmj.77.906.286h · Cited by 608
Oertel, M., Boscardin, W. J., Obrist, W. D., Glenn, T. C., McArthur, D. L., Gravori, T., Lee, J. H., & Martin, N. A. (2005) · Journal of Neurosurgery · doi:10.3171/jns.2005.103.5.0812 · Cited by 227
ZHAO, J., ZHOU, D., GUO, J., REN, Z., ZHOU, L., WANG, S., XU, B., & WANG, R. (2006) · Neurologia medico-chirurgica · doi:10.2176/nmc.46.421 · Cited by 117
Metadata
- Authors
- Allen, G. S., Ahn, H. S., Preziosi, T. J., Battye, R., Boone, S. C., Chou, S. N., Kelly, D. L., Weir, B. K., Crabbe, R. A., Lavik, P. J., Rosenbloom, S. B., Dorsey, F. C., Ingram, C. R., Mellits, D. E., Bertsch, L. A., Boisvert, D. P. J., Hundley, M. B., Johnson, R. K., Strom, J. A., & Transou, C. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-03-17
- Volume
- 308
- Issue
- 11
- Pages
- 619-624
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2317146405
- Cited by
- 1,195
- References
- 0
- FWCI
- 48.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage. https://app.cochat.ai/papers/10.1056/nejm198303173081103
- The paper
- Allen, G. S., Ahn, H. S., Preziosi, T. J., Battye, R., Boone, S. C., Chou, S. N., Kelly, D. L., Weir, B. K., Crabbe, R. A., Lavik, P. J., Rosenbloom, S. B., Dorsey, F. C., Ingram, C. R., Mellits, D. E., Bertsch, L. A., Boisvert, D. P. J., Hundley, M. B., Johnson, R. K., Strom, J. A., & Transou, C. R. (1983). Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage. New England Journal of Medicine. https://doi.org/10.1056/nejm198303173081103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
