The DOI matches its Crossref record.
Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon
Abstract
Raynaud's phenomenon may cause severe digital pain and functional disability, particularly in patients with underlying connective-tissue disease. The treatment of this condition is difficult.1 Nifedipine, a slow calcium-channel antagonist, causes vascular smooth-muscle relaxation and relief of arterial vasospasm.2 3 4 Nifedipine-induced vasodilation has been shown to result in a fall in peripheral vascular resistance and an increase in peripheral blood flow.5 Nifedipine increases the skin blood flow by 50 to 150 per cent in normal persons and has also been shown in vitro to inhibit norepinephrine-induced vasospasm of rabbit and human peripheral arteries and veins.6 , 7 The calcium-channel blockers nifedipine and verapamil have . . .
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Citations
Cited by
Update of EULAR recommendations for the treatment of systemic sclerosis
Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209909 · Cited by 1,104
Self-citationBadesch, D. B., Tapson, V. F., McGoon, M. D., Brundage, B. H., Rubin, L. J., Wigley, F. M., Rich, S., Barst, R. J., Barrett, P. S., Kral, K. M., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-6-200003210-00002 · Cited by 1,075
Self-citationFish Oil, Raynaud's Syndrome, and Undiscovered Public Knowledge
Swanson, D. R. (1986) · Perspectives in Biology and Medicine · doi:10.1353/pbm.1986.0087 · Cited by 866
Dziadzio, M., Denton, C. P., Smith, R., Howell, K., Blann, A., Bowers, E., & Black, C. M. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199912)42:12<2646::aid-anr21>3.0.co;2-t · Cited by 318
Metadata
- Authors
- Rodeheffer, R. J., Rommer, J. A., Wigley, F., & Smith, C. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-04-14
- Volume
- 308
- Issue
- 15
- Pages
- 880-883
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1999701858
- Cited by
- 242
- References
- 0
- FWCI
- 20.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon. https://app.cochat.ai/papers/10.1056/nejm198304143081507
- The paper
- Rodeheffer, R. J., Rommer, J. A., Wigley, F., & Smith, C. R. (1983). Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon. New England Journal of Medicine. https://doi.org/10.1056/nejm198304143081507
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
