The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Variable Bioavailability of Oral Mercaptopurine: Is Maintenance Chemotherapy in Acute Lymphoblastic Leukemia Being Optimally Delivered?
Abstract
Induction therapy is now successful in producing a complete remission in more than 90 per cent of patients with acute lymphoblastic leukemia.1 , 2 However, maintenance of remission remains a major problem, since a third of patients with a standard risk and approximately 80 per cent of patients with a high risk relapse despite periodic intensification of chemotherapy and continual maintenance chemotherapy.3 The daily administration of oral mercaptopurine forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia; most treatment regimens also include weekly or biweekly administration of oral methotrexate. The rationale for giving mercaptopurine orally has been based on clinical studies . . .
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Citations
Cites
Noncompartmental Determination of the Steady‐State Volume of Distribution
Benet, L. Z., & Galeazzi, R. L. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600680845 · Cited by 735
BURCHENAL, J. H., MURPHY, M. L., ELLISON, R. R., SYKES, M. P., TAN, T. C., LEONE, L. A., KARNOF-SKY, D. A., CRAVER, L. F., DARGEON, H. W., & RHOADS, C. P. (1953) · Blood · doi:10.1182/blood.v8.11.965.965 · Cited by 397
ACUTE LEUKEMIA GROUP B, FREIREICH, E. J., GEHAN, E., FREI, E., SCHROEDER, L. R., WOLMAN, I. J., ANBARI, R., BURGERT, E. O., MILLS, S. D., PINKEL, D., et al. (1963) · Blood · doi:10.1182/blood.v21.6.699.699 · Cited by 308
Influence of food and diet on gastrointestinal drug absorption: A review
Welling, P. G. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01061694 · Cited by 307
Drug dosage and remission duration in childhood lymphocytic leukemia
Pinkel, D. P., Hernandez, K., Borella, L. D., Holton, C. P., Aur, R. J. A., Samoy, G., & Pratt, C. B. (1971) · Cancer · Cited by 234
The Distribution of Xanthine Oxidase I
Morgan, E. J. (1926) · Biochemical Journal · doi:10.1042/bj0201282 · Cited by 93
Ding, T. L., & Benet, L. Z. (1979) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)09246-3 · Cited by 36
Effects of Allopurinol on 6-Mercaptopurine Therapy in Neoplastic Diseases
Rundles, R. W. (1966) · Annals of the Rheumatic Diseases · doi:10.1136/ard.25.suppl_6.655 · Cited by 21
Cited by
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Oral ketamine for the treatment of pain and treatment-resistant depression
Schoevers, R. A., Chaves, T. V., Balukova, S. M., Rot, M. A. H., & Kortekaas, R. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.165498 · Cited by 81
Metadata
- Authors
- Zimm, S., Collins, J. M., Riccardi, R., O'Neill, D., Narang, P. K., Chabner, B., & Poplack, D. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-04-28
- Volume
- 308
- Issue
- 17
- Pages
- 1005-1009
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2072032394
- Cited by
- 262
- References
- 8
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Variable Bioavailability of Oral Mercaptopurine: Is Maintenance Chemotherapy in Acute Lymphoblastic Leukemia Being Optimally Delivered? https://app.cochat.ai/papers/10.1056/nejm198304283081705
- The paper
- Zimm, S., Collins, J. M., Riccardi, R., O'Neill, D., Narang, P. K., Chabner, B., & Poplack, D. G. (1983). Variable Bioavailability of Oral Mercaptopurine: Is Maintenance Chemotherapy in Acute Lymphoblastic Leukemia Being Optimally Delivered? New England Journal of Medicine. https://doi.org/10.1056/nejm198304283081705
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
