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Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia
Abstract
We treated seven patients who had progressive hairy-cell leukemia with daily doses of 3 million units of partially pure alpha (leukocyte) interferon by the intramuscular route. Three patients had a complete remission, and four had a partial remission, according to strict criteria for a response. After treatment, bone-marrow aspirates showed an absence of leukemia cells in three patients and 5 per cent or fewer in three others. Normalization of subnormal peripheral-blood values occurred in six of six patients with anemia, in seven of seven with granulocytopenia, and in four of four with thrombocytopenia. Remissions have been maintained for over 6 to over 10 months. Alpha interferon appears to be highly effective in patients with hairy-cell leukemia.
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Cited by
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Yang, Q., Guo, N., Zhou, Y., Chen, J., Wei, Q., & Han, M. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.04.004 · Cited by 471
Clinical investigation of human alpha interferon in chronic myelogenous leukemia
Talpaz, M., Kantarjian, H., McCredie, K., Keating, M., Trujillo, J., & Gutterman, J. (1987) · Blood · doi:10.1182/blood.v69.5.1280.1280 · Cited by 328
Self-citationTreatment of hairy cell leukemia with recombinant alpha-interferon
Quesada, Jr., Hersh, E., Manning, J., Reuben, J., Keating, M., Schnipper, E., Itri, L., & Gutterman, J. (1986) · Blood · doi:10.1182/blood.v68.2.493.493 · Cited by 278
Self-citationInterferons: role in cancer therapy
Abdolvahab, M. H., Darvishi, B., Zarei, M., Majidzadeh-A, K., & Farahmand, L. (2020) · Immunotherapy · doi:10.2217/imt-2019-0217 · Cited by 50
Metadata
- Authors
- Quesada, J. R., Reuben, J., Manning, J. T., Hersh, E. M., & Gutterman, J. U.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-01-05
- Volume
- 310
- Issue
- 1
- Pages
- 15-18
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1995628336
- Cited by
- 820
- References
- 0
- FWCI
- 67.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia. https://app.cochat.ai/papers/10.1056/nejm198401053100104
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- Quesada, J. R., Reuben, J., Manning, J. T., Hersh, E. M., & Gutterman, J. U. (1984). Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia. New England Journal of Medicine. https://doi.org/10.1056/nejm198401053100104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
