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Incidence and Prognosis of Unrecognized Myocardial Infarction: An Update on the Framingham Study
Abstract
Of 708 myocardial infarctions among 5127 participants in the Framingham Study, more than 25 per cent were discovered only through the appearance of new diagnostic evidence during routine biennial electrocardiographic examinations. Of these unrecognized infarctions almost half were "silent," and the others caused atypical symptoms. The proportion of all infarcts that were unrecognized was higher in women and in older men. Such infarcts were uncommon in persons with angina. Unrecognized infarctions were as likely as recognized ones to cause death, heart failure, or strokes. Recurrent infarctions were more common in women with recognized than with unrecognized infarcts, but this difference was not present in men. Recurrent infarctions were more likely to be recognized than were first infarctions. We conclude that unrecognized infarctions are common and have as serious a prognosis as recognized infarctions.
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Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
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Mangano, D. T., Browner, W. S., Hollenberg, M., London, M. J., Tubau, J. F., & Tateo, I. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012273232601 · Cited by 992
Alexander, K. P., Newby, L. K., Cannon, C. P., Armstrong, P. W., Gibler, W. B., Rich, M. W., Van de Werf, F., White, H. D., Weaver, W. D., Naylor, M. D., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.182615 · Cited by 914
Newman, A. B., Shemanski, L., Manolio, T. A., Cushman, M., Mittelmark, M., Polak, J. F., Powe, N. R., & Siscovick, D. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.538 · Cited by 871
White, A. D., Folsom, A. R., Chambless, L. E., Sharret, A. R., Yang, K., Conwill, D., Higgins, M., Williams, O. D., Tyroler, H. A., & The ARIC Investigators (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00041-0 · Cited by 688
Metadata
- Authors
- Kannel, W. B., & Abbott, R. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-11
- Volume
- 311
- Issue
- 18
- Pages
- 1144-1147
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2075788673
- Cited by
- 1,018
- References
- 1
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Incidence and Prognosis of Unrecognized Myocardial Infarction: An Update on the Framingham Study. https://app.cochat.ai/papers/10.1056/nejm198411013111802
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- Kannel, W. B., & Abbott, R. D. (1984). Incidence and Prognosis of Unrecognized Myocardial Infarction: An Update on the Framingham Study. New England Journal of Medicine. https://doi.org/10.1056/nejm198411013111802
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
