The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Delay in the Fetal Globin Switch in Infants of Diabetic Mothers
Abstract
In the normal fetus, a switch from production of hemoglobin F (alpha 2 gamma 2) to hemoglobin A (alpha 2 beta 2) occurs at 28 to 34 weeks of gestation. In the fetus with beta-hemoglobinopathy or beta-thalassemia, this switch proceeds despite the morbidity that results when production of beta-globin is abnormal or reduced. Since insulin has recently been shown to induce renewed expression of some inactive genes, we studied globin biosynthesis during the natural evolution of the fetal globin switch under conditions of hyperinsulinemia, which occurs in infants of diabetic mothers. Such infants develop in a hyperglycemic environment, which produces reactive hyperinsulinemia. The normal increase in beta-globin production from pre-switch levels did not occur in 9 of 10 such infants at term, as compared with 11 normal infants, in whom the switch occurred by 36 to 39 weeks of gestation (P less than 0.0001). The delay in the switch from gamma-globin to beta-globin in this unique clinical setting may allow identification of physiologic factors that can modulate developmental gene suppression.
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Citations
Cites
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831
5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia
Ley, T. J., DeSimone, J., Anagnou, N. P., Keller, G. H., Humphries, R. K., Turner, P. H., Young, N. S., Heller, P., & Nienhuis, A. W. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212093072401 · Cited by 490
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.
DeSimone, J., Heller, P., Hall, L., & Zwiers, D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4428 · Cited by 384
Natural History of Sickle Cell Anemia in Saudi Arabs: A Study of 270 Subjects
PERRINE, R. P., PEMBREY, M. E., JOHN, P., PERRINE, S., & SHOUP, F. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-88-1-1 · Cited by 284
Self-citationSickle cell disease in Saudi Arabs in early childhood
Perrine, R. P., John, P., Pembrey, M., & Perrine, S. (1981) · Archives of Disease in Childhood · doi:10.1136/adc.56.3.187 · Cited by 52
Self-citation
Cited by
Pathogenesis and Treatment of Sickle Cell Disease
Bunn, H. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709113371107 · Cited by 1,154
The switch from fetal to adult hemoglobin.
Sankaran, V. G., & Orkin, S. H. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011643 · Cited by 333
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.
Atweh, G. F., Sutton, M., Nassif, I. I., Boosalis, V., Dover, G. J., Wallenstein, S. R., Wright, E. C., McMahon, L. C., Stamatoyannopoulos, G., Faller, D. V., et al. (1999) · PubMed · doi:10.1182/blood.v93.6.1790.406k27_1790_1797 · Cited by 253
Self-citationDevelopmental biology of erythropoiesis
Palis, J., & Segel, G. B. (1998) · Blood Reviews · doi:10.1016/s0268-960x(98)90022-4 · Cited by 132
Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease
Atweh, G. F., & Schechter, A. N. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200103000-00010 · Cited by 66
Metadata
- Authors
- Perrine, S. P., Greene, M. F., & Faller, D. V.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-02-07
- Volume
- 312
- Issue
- 6
- Pages
- 334-338
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2056046551
- Cited by
- 172
- References
- 5
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perrine, S. P., Greene, M. F., & Faller, D. V. (1985). Delay in the Fetal Globin Switch in Infants of Diabetic Mothers. New England Journal of Medicine. https://doi.org/10.1056/nejm198502073120602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
