The DOI matches its Crossref record.
The Thrombolysis in Myocardial Infarction (TIMI) Trial: Phase I Findings
Abstract
Acute myocardial infarction is a major public health problem that resulted in an estimated 676,000 hospital admissions in 1983.1 Thrombolytic therapy with reperfusion of ischemic, not yet necrotic myocardium is a promising but unproved addition to conventional coronary care, which may actually limit infarct size if given soon after the onset of infarction.2 3 4 5 6 Ligation of canine coronary arteries followed by ligature release and reperfusion has demonstrated that necrosis is complete by six hours.7 , 8 The time course of necrosis after coronary occlusion in human beings with chronic coronary artery disease is probably similar. Therefore, if thrombolytic therapy is to have a . . .
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Citations
Cited by
Higashida, R. T., & Furlan, A. J. (2003) · Stroke · doi:10.1161/01.str.0000082721.62796.09 · Cited by 1,543
Myocardial No-Reflow in Humans
Niccoli, G., Burzotta, F., Galiuto, L., & Crea, F. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.054 · Cited by 853
Demaerschalk, B. M., Kleindorfer, D. O., Adeoye, O. M., Demchuk, A. M., Fugate, J. E., Grotta, J. C., Khalessi, A. A., Levy, E. I., Palesch, Y. Y., Prabhakaran, S., et al. (2016) · Stroke · doi:10.1161/str.0000000000000086 · Cited by 670
Grines, C. L., Marsalese, D. L., Brodie, B., Griffin, J., Donohue, B., Costantini, C. R., Balestrini, C., Stone, G., Wharton, T., Esente, P., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00031-x · Cited by 276
Stone, G. W., Marsalese, D., Brodie, B. R., Griffin, J. J., Donohue, B., Costantini, C., Balestrini, C., Wharton, T., Esente, P., Spain, M., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00088-0 · Cited by 271
Metadata
- Authors
- The TIMI Study Group*
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-04-04
- Volume
- 312
- Issue
- 14
- Pages
- 932-936
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4235858444
- Cited by
- 3,188
- References
- 0
- FWCI
- 89.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Thrombolysis in Myocardial Infarction (TIMI) Trial: Phase I Findings. https://app.cochat.ai/papers/10.1056/nejm198504043121437
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- The TIMI Study Group*. (1985). The Thrombolysis in Myocardial Infarction (TIMI) Trial: Phase I Findings. New England Journal of Medicine. https://doi.org/10.1056/nejm198504043121437
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
