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Cited by 816

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Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings

Beatty, Patrick G., Clift, Reginald A., Mickelson, Eric M., Nisperos, Brenda B., Flournoy, Nancy, Martin, Paul J., Sanders, Jean E., Stewart, Patricia, Buckner, C. Dean, Storb, Rainer, Thomas, E. Donnall, Hansen, John A.·1985·New England Journal of Medicine

Abstract

Marrow transplantation has generally been limited to patients with a sibling who is genotypically identical for HLA. In a study of the acceptable limits of HLA incompatibility, 105 consecutive patients with hematologic cancers who received marrow grafts from haploidentical donors (study group) were compared with 728 similar patients concurrently receiving grafts from HLA genotypically identical siblings (control group). The unshared haplotypes differed variably: 12 were phenotypically but not genotypically identical for HLA-A, HLA-B, and HLA-D; 63 differed at one locus (A, B, or D); 24 at two loci; and 6 at three. A higher proportion of study patients had delayed engraftment, granulocytopenia, or graft rejection. Acute graft versus host disease occurred earlier and with greater frequency in study patients. The risk of the disease did not correlate with disparity for Class I (A or B) versus Class II (D-region) loci. Thus, incompatibility for HLA has an important effect on the course after clinical marrow transplantation. In spite of these complications, there was no statistically significant difference in the survival of the study patients and control patients who received their transplants during remission.

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Metadata

Authors
Beatty, P. G., Clift, R. A., Mickelson, E. M., Nisperos, B. B., Flournoy, N., Martin, P. J., Sanders, J. E., Stewart, P., Buckner, C. D., Storb, R., Thomas, E. D., & Hansen, J. A.
Venue
New England Journal of Medicine
Published
1985-09-26
Volume
313
Issue
13
Pages
765-771
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2317642686
Cited by
816
References
1
FWCI
16.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings. https://app.cochat.ai/papers/10.1056/nejm198509263131301
The paper
Beatty, P. G., Clift, R. A., Mickelson, E. M., Nisperos, B. B., Flournoy, N., Martin, P. J., Sanders, J. E., Stewart, P., Buckner, C. D., Storb, R., Thomas, E. D., & Hansen, J. A. (1985). Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings. New England Journal of Medicine. https://doi.org/10.1056/nejm198509263131301

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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