The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics
Abstract
We investigated whether captopril, an angiotensin-converting-enzyme inhibitor, would reduce proteinuria in patients with advanced diabetic nephropathy. Captopril (37.5 mg given in divided doses three times daily) was administered to 10 azotemic diabetics with heavy proteinuria. Urinary protein decreased promptly within two weeks (from 10.6 +/- 2.2 to 6.1 +/- 1.4 g per day [mean +/- S.E.M.]; P less than 0.01). The decrease in proteinuria did not coincide with a fall in systemic blood pressure or in the blood glucose concentration. Serum creatinine and potassium values did not change in any of the patients except one. We suggest that captopril caused a decrease in intrarenal hypertension, which contributed to the reduction of urinary protein excretion. The therapeutic value of this intervention remains to be established.
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Citations
Cites
Sodium, renin, aldosterone, catecholamines, and blood pressure in diabetes mellitus
de Châtel, R., Weidmann, P., Flammer, J., Ziegler, W. H., Beretta-Piccoli, C., Vetter, W., & Reubi, F. C. (1977) · Kidney International · doi:10.1038/ki.1977.132 · Cited by 182
Cited by
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
Lewis, E. J., Hunsicker, L. G., Bain, R. P., & Rohde, R. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292004 · Cited by 5,394
Short and long term effects of antihypertensive therapy in the diabetic rat
Anderson, S., Rennke, H. G., Garcia, D. L., Brenner, B. M., Riley, S. L., & Sandstrom, D. J. (1989) · Kidney International · doi:10.1038/ki.1989.227 · Cited by 306
Heterogeneous nature of renal lesions in type II diabetes.
Gambara, V, Mecca, G., Remuzzi, G., & Bertani, T. (1993) · Journal of the American Society of Nephrology · doi:10.1681/asn.v381458 · Cited by 257
Metadata
- Authors
- Taguma, Y., Kitamoto, Y., Futaki, G., Ueda, H., Monma, H., Ishizaki, M., Takahashi, H., Sekino, H., & Sasaki, Y.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-12-26
- Volume
- 313
- Issue
- 26
- Pages
- 1617-1620
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1964377393
- Cited by
- 412
- References
- 1
- FWCI
- 33.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taguma, Y., Kitamoto, Y., Futaki, G., Ueda, H., Monma, H., Ishizaki, M., Takahashi, H., Sekino, H., & Sasaki, Y. (1985). Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics. New England Journal of Medicine. https://doi.org/10.1056/nejm198512263132601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
