The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Diltiazem and Reinfarction in Patients with Non-Q-Wave Myocardial Infarction
Abstract
We performed a multicenter, double-blind, randomized study to evaluate the effect of diltiazem on reinfarction after a non-Q-wave myocardial infarction. Nine centers enrolled 576 patients: 287 received diltiazem (90 mg every six hours) and 289 received placebo. Treatment was initiated 24 to 72 hours after the onset of infarction and continued for up to 14 days. The primary end point, reinfarction, was defined as an abnormal reelevation of MB creatine kinase in plasma within 14 days. Reinfarction occurred in 27 patients in the placebo group (9.3 percent) and in 15 in the diltiazem group (5.2 percent)--a 51.2 percent reduction in cumulative life-table incidence (P = 0.0297; 90 percent confidence interval, 7 to 67 percent). Diltiazem reduced the frequency of refractory postinfarction angina (a secondary end point) by 49.7 percent (P = 0.0345; 90 percent confidence interval, 6 to 73 percent). Mortality was similar in the two groups (3.1 and 3.8 percent, respectively, in the placebo and diltiazem groups), but adverse drug reactions (most of which were mild) were more common in the diltiazem group. Nevertheless, the drug was well tolerated, despite concurrent treatment with beta-blockers in 61 percent of the patients. We conclude that diltiazem was effective in preventing early reinfarction and severe angina after non-Q-wave infarction and that it was also safe and generally well tolerated.
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Cites
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2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., Levin, T. N., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.013 · Cited by 1,510
Self-citationAmsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000133 · Cited by 1,254
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Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00889-5 · Cited by 963
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Metadata
- Authors
- Gibson, R. S., Boden, W. E., Theroux, P., Strauss, H. D., Pratt, C. M., Gheorghiade, M., Capone, R. J., Crawford, M. H., Schlant, R. C., Kleiger, R. E., Young, P. M., Schechtman, K., Perryman, M. B., Roberts, R., & the Diltiazem Reinfarction Study Group
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-08-14
- Volume
- 315
- Issue
- 7
- Pages
- 423-429
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2322661993
- Cited by
- 537
- References
- 24
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gibson, R. S., Boden, W. E., Theroux, P., Strauss, H. D., Pratt, C. M., Gheorghiade, M., Capone, R. J., Crawford, M. H., Schlant, R. C., Kleiger, R. E., Young, P. M., Schechtman, K., Perryman, M. B., Roberts, R., & the Diltiazem Reinfarction Study Group. (1986). Diltiazem and Reinfarction in Patients with Non-Q-Wave Myocardial Infarction. New England Journal of Medicine. https://doi.org/10.1056/nejm198608143150704
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
