The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure
Abstract
To define the relation between atrial pressures and the release of atrial natriuretic peptide, we measured plasma concentrations of the peptide in 26 patients with cardiac disease--11 with normal atrial pressures and 15 with elevated atrial pressures (11 of these 15 had elevated pressures in both atria). Mean peptide levels (+/- SEM) in the peripheral venous blood were increased in the 11 patients with cardiac disease and normal atrial pressures, as compared with 60 healthy controls (48 +/- 14 vs. 17 +/- 2 pmol per liter). In the patients with elevated atrial pressures, peptide concentrations were increased twofold in peripheral venous, right atrial, pulmonary arterial, and systemic arterial plasma, as compared with the concentrations in the patients with normal atrial pressures. A step-up in peptide concentration was seen between the venous and right atrial plasma (P less than 0.002) and between the pulmonary and systemic arterial plasma (P less than 0.01), suggesting release of the peptide from the atria. A linear relation was found between right atrial pressure and right atrial peptide concentration (r = 0.835, P less than 0.001) and between pulmonary wedge pressure and the systemic arterial peptide concentration (r = 0.866, P less than 0.001). Right atrial pressure and the peptide concentration both increased with exercise testing in the nine patients evaluated. We conclude that the release of atrial natriuretic peptide is at least partly regulated by right and left atrial pressures. Distinguishing the relative contributions of the two atria and defining the role of peptide release in the pathogenesis of heart failure will require further investigation.
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Cites
de Bold, A. J., Borenstein, H. B., Veress, A. T., & Sonnenberg, H. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90370-2 · Cited by 3,148
Atrial natriuretic factor—a circulating hormone stimulated by volume loading
Lang, R. E., Thölken, H., Ganten, D., Luft, F. C., Ruskoaho, H., & Unger, T. (1985) · Nature · doi:10.1038/314264a0 · Cited by 1,230
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kangawa, K., & Matsuo, H. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91077-5 · Cited by 1,149
Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency
Baldwin, K. M., Hooker, A. M., Campbell, P. J., & Lewis, R. E. (1978) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1978.235.3.c97 · Cited by 1,118
Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria
Currie, M. G., Geller, D. M., Cole, B. R., Boylan, J. G., YuSheng, W., Holmberg, S. W., & Needleman, P. (1983) · Science · doi:10.1126/science.6857267 · Cited by 709
Purification and Sequence Analysis of Bioactive Atrial Peptides (Atriopeptins)
Currie, M. G., Geller, D. M., Cole, B. R., Siegel, N. R., Fok, K. F., Adams, S. P., Eubanks, S. R., Galluppi, G. R., & Needleman, P. (1984) · Science · doi:10.1126/science.6419347 · Cited by 523
PLASMA ATRIAL NATRIURETIC PEPTIDE IN CARDIAC DISEASE AND DURING INFUSION IN HEALTHY VOLUNTEERS
Tikkanen, I., Metsärinne, K., Fyhrquist, F., & Leidenius, R. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90178-3 · Cited by 466
Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide
Atlas, S. A., Kleinert, H. D., Camargo, M. J. F., Januszewicz, A., Sealey, J. E., Laragh, J. H., Schilling, J., Lewicki, J. A., Johnson, L. K., & Maack, T. (1984) · Nature · doi:10.1038/309717a0 · Cited by 427
Alterations in vasomotor tone in congestive heart failure
Zelis, R., & Flaim, S. F. (1982) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(82)90012-3 · Cited by 363
Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptide
Oikawa, S., Imai, M., Ueno, A., Tanaka, S., Noguchi, T., Nakazato, H., Kangawa, K., Fukuda, A., & Matsuo, H. (1984) · Nature · doi:10.1038/309724a0 · Cited by 317
Cited by
Tsutamoto, T., Wada, A., Maeda, K., Hisanaga, T., Maeda, Y., Fukai, D., Ohnishi, M., Sugimoto, Y., & Kinoshita, M. (1997) · Circulation · doi:10.1161/01.cir.96.2.509 · Cited by 963
Edwards, B. S., Zimmerman, R. S., Schwab, T. R., Heublein, D. M., & Burnett, J. C. (1988) · Circulation Research · doi:10.1161/01.res.62.2.191 · Cited by 484
Greenberg, B., Quinones, M. A., Koilpillai, C., Limacher, M., Shindler, D., Benedict, C., & Shelton, B. (1995) · Circulation · doi:10.1161/01.cir.91.10.2573 · Cited by 473
Omland, T., Lie, R. T., Aakvaag, A., Aarsland, T., & Dickstein, K. (1994) · Circulation · doi:10.1161/01.cir.89.4.1573 · Cited by 403
Anand, I. S., Ferrari, R., Kalra, G. S., Wahi, P. L., Poole-Wilson, P. A., & Harris, P. C. (1989) · Circulation · doi:10.1161/01.cir.80.2.299 · Cited by 375
Metadata
- Authors
- Raine, A. E. G., Erne, P., Bürgisser, E., Müller, F. B., Bolli, P., Burkart, F., & Bühler, F. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-08-28
- Volume
- 315
- Issue
- 9
- Pages
- 533-537
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2041179424
- Cited by
- 585
- References
- 14
- FWCI
- 56.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure. https://app.cochat.ai/papers/10.1056/nejm198608283150901
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- Raine, A. E. G., Erne, P., Bürgisser, E., Müller, F. B., Bolli, P., Burkart, F., & Bühler, F. R. (1986). Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure. New England Journal of Medicine. https://doi.org/10.1056/nejm198608283150901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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