The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Increased Risk of Cancer in the Peutz–Jeghers Syndrome
Abstract
The Peutz-Jeghers syndrome is an autosomal dominant hereditary disease characterized by hamartomatous polyps of the gastrointestinal tract and by mucocutaneous melanin deposits. The frequency of cancer in this syndrome has not been studied extensively. Therefore, we investigated 31 patients with the Peutz-Jeghers syndrome who were followed from 1973 to 1985. All cases of cancer were verified by histopathological review. Cancer developed in 15 of the 31 patients (48 percent)--gastrointestinal carcinomas in 4, nongastrointestinal carcinomas in 10, and multiple myeloma in 1. In addition, adenomatous polyps of the stomach and colon occurred in three other patients. The cancers were diagnosed when the patients were relatively young, but after the Peutz-Jeghers syndrome had been diagnosed (interval between diagnoses, 25 +/- 20 years; range, 1 to 64). According to relative-risk analysis, the observed development of cancer in the patients with the syndrome was 18 times greater than expected in the general population (P less than 0.0001). Our results suggest that patients with the Peutz-Jeghers syndrome have an increased risk for the development of cancer at gastrointestinal and nongastrointestinal sites.
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Cites
(1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-66-3-628_2 · Cited by 970
Jeghers, H., McKusick, V. A., & Katz, K. H. (1949) · New England Journal of Medicine · doi:10.1056/nejm194912292412601 · Cited by 656
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HYDROCORTISONE IN SEVERE MYOCARDIAL INFARCTION
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Perzin, K. H., & Bridge, M. F. (1982) · Cancer · doi:10.1002/1097-0142(19820301)49:5<971::aid-cncr2820490522>3.0.co;2-1 · Cited by 177
Peutz-Jeghers syndrome with feminizing sertoli cell tumor
Cantú, J. M., Rivera, H., Ocampo-Campos, R., Bedolla, N., Cortés-Gallegos, V., Gonzalez-Mendoza, A., Díaz, M., & Hernández, A. (1980) · Cancer · doi:10.1002/1097-0142(19800701)46:1<223::aid-cncr2820460137>3.0.co;2-8 · Cited by 90
Computer Searching of the Medical Literature
Haynes, R. B., McKIBBON, K. A., WALKER, C. J., MOUSSEAU, J., BAKER, L. M., FITZGERALD, D., GUYATT, G., & NORMAN, G. R. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-5-812 · Cited by 79
Feminizing sex cord tumor with annular tubules in a boy with Peutz-Jeghers syndrome
Dubois, R. S., Hoffman, W. H., Krishman, T. H., Rising, J. A., Tolia, V. K., Sy, D. A., & Chang, C. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80705-1 · Cited by 53
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International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354
Kamisawa, T., Wood, L. D., Itoi, T., & Takaori, K. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00141-0 · Cited by 2,212
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Kamisawa, T., Jang, J. Y., Levy, P., Ohtsuka, T., Salvia, R., Shimizu, Y., Tada, M., & Wolfgang, C. L. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.007 · Cited by 1,797
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,445
Self-citationPancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors
Klein, A. P. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00457-x · Cited by 1,258
Metadata
- Authors
- Giardiello, F. M., Welsh, S. B., Hamilton, S. R., Offerhaus, G. J. A., Gittelsohn, A. M., Booker, S. V., Krush, A. J., Yardley, J. H., & Luk, G. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-06-11
- Volume
- 316
- Issue
- 24
- Pages
- 1511-1514
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341084019
- Cited by
- 848
- References
- 8
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giardiello, F. M., Welsh, S. B., Hamilton, S. R., Offerhaus, G. J. A., Gittelsohn, A. M., Booker, S. V., Krush, A. J., Yardley, J. H., & Luk, G. D. (1987). Increased Risk of Cancer in the Peutz–Jeghers Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm198706113162404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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