The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Alteration in the Natural History of Neurosyphilis by Concurrent Infection with the Human Immunodeficiency Virus
Abstract
Within the past 18 months, we have seen four cases of neurosyphilis at our institution (two of meningovascular syphilis, one of acute syphilitic meningitis, and one of asymptomatic neurosyphilis) in young homosexual men with serologic evidence of exposure to human immunodeficiency virus (HIV). Two of the four patients had neurosyphilis despite previous adequate therapy for early syphilis with benzathine penicillin. Meningovascular syphilis developed in one patient within four months after a primary infection, in a manner consistent with an accelerated course of syphilitic infection. These findings suggest the possibility that HIV infection may alter the natural course of syphilis because of the profound defects in cell-mediated immunity it causes. The possible potentiating effects of HIV on Treponema pallidum infection suggest the need for lumbar puncture in the evaluation of HIV-seropositive patients with syphilis, as well as modifications of the currently recommended treatment regimens for primary, secondary, and latent syphilis and neurosyphilis in this patient population. Neurosyphilis should probably be added to the growing list of infectious complications of the acquired immunodeficiency syndrome (AIDS) and may be the first such complication to appear.
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Cites
Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients
Snider, W. D., Simpson, D. M., Nielsen, S., Gold, W. M. J., Metroka, C. E., & Posner, J. B. (1983) · Annals of Neurology · doi:10.1002/ana.410140404 · Cited by 1,367
Immunopathogenesis of the Acquired Immunodeficiency Syndrome
BOWEN, D. L., LANE, H. C., & FAUCI, A. S. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-5-704 · Cited by 328
The Oslo study of the natural history of untreated syphilis
Clark, E. G., & Danbolt, N. (1955) · Journal of Chronic Diseases · doi:10.1016/0021-9681(55)90139-9 · Cited by 205
Neurosyphilis in the antibiotic era
Burke, J. M., & Schaberg, D. R. (1985) · Neurology · doi:10.1212/wnl.35.9.1368 · Cited by 115
Bayne, L. L. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520020031012 · Cited by 59
Examination of Cerebrospinal Fluid in Patients with Syphilis
Jaffe, H. W., & Kabins, S. A. (1982) · Clinical Infectious Diseases · doi:10.1093/clinids/4.supplement_4.s842 · Cited by 54
Failure of Recommended Treatment for Secondary Syphilis
Markovitz, D. M., Beutner, K. R., Maggio, R. P., & Reichman, R. C. (1986) · JAMA · doi:10.1001/jama.1986.03370130123036 · Cited by 44
Titus, R. G., & Weiser, R. S. (1979) · The Journal of Infectious Diseases · doi:10.1093/infdis/140.6.904 · Cited by 34
Cited by
Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features
Singh, A. E., & Romanowski, B. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.187 · Cited by 638
Lukehart, S. A., Hook, E. W., Baker-Zander, S. A., Collier, A. C., Critchlow, C. W., & Handsfield, H. H. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-11-855 · Cited by 603
Rolfs, R. T., Joesoef, M. R., Hendershot, E. F., Rompalo, A. M., Augenbraun, M. H., Chiu, M., Bolan, G., Johnson, S. C., French, P., Steen, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707313370504 · Cited by 550
Hook, E. W., & Marra, C. M. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204163261606 · Cited by 470
Ropper, A. H. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1906228 · Cited by 319
Metadata
- Authors
- Johns, D. R., Tierney, M., & Felsenstein, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-06-18
- Volume
- 316
- Issue
- 25
- Pages
- 1569-1572
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2330788102
- Cited by
- 566
- References
- 8
- FWCI
- 36.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Johns, D. R., Tierney, M., & Felsenstein, D. (1987). Alteration in the Natural History of Neurosyphilis by Concurrent Infection with the Human Immunodeficiency Virus. New England Journal of Medicine. https://doi.org/10.1056/nejm198706183162503
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
