The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neurologic Relapse after Benzathine Penicillin Therapy for Secondary Syphilis in a Patient with HIV Infection
Abstract
TREPONEMA pallidum, the etiologic agent of syphilis, may be detected in the cerebrospinal fluid during early infection. The recommended therapeutic agent for primary, secondary, and latent syphilis, benzathine penicillin, does not reach treponemicidal levels within the cerebrospinal fluid, and concerns have been raised that current treatment regimens may be inadequate, particularly in patients who harbor spirochetes in their central nervous systems.We report the failure of benzathine penicillin in the treatment of secondary syphilis in a homosexual man who was seropositive for human immunodeficiency virus (HIV). After therapy, his serum Venereal Disease Research Laboratory (VDRL) test titers decreased appropriately . . .
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Citations
Cites
Neurosyphilis and Penicillin Levels in Cerebrospinal Fluid
Mohr, J. A. (1976) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1976.03270200046031 · Cited by 178
Cerebrospinal Fluid Penicillin Levels During Therapy for Latent Syphilis
Ducas, J. (1981) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1981.03320220033020 · Cited by 48
Cited by
Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features
Singh, A. E., & Romanowski, B. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.187 · Cited by 638
Lukehart, S. A., Hook, E. W., Baker-Zander, S. A., Collier, A. C., Critchlow, C. W., & Handsfield, H. H. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-11-855 · Cited by 603
Self-citationRolfs, R. T., Joesoef, M. R., Hendershot, E. F., Rompalo, A. M., Augenbraun, M. H., Chiu, M., Bolan, G., Johnson, S. C., French, P., Steen, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707313370504 · Cited by 550
Marra, C. M., Maxwell, C. L., Smith, S. L., Lukehart, S. A., Rompalo, A. M., Eaton, M., Stoner, B. P., Augenbraun, M., Barker, D. E., Corbett, J. J., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/381227 · Cited by 491
Self-citationHook, E. W., & Marra, C. M. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204163261606 · Cited by 470
Metadata
- Authors
- Berry, C. D., Hooton, T. M., Collier, A. C., & Lukehart, S. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-06-18
- Volume
- 316
- Issue
- 25
- Pages
- 1587-1589
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2007404003
- Cited by
- 341
- References
- 2
- FWCI
- 30.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neurologic Relapse after Benzathine Penicillin Therapy for Secondary Syphilis in a Patient with HIV Infection. https://app.cochat.ai/papers/10.1056/nejm198706183162507
- The paper
- Berry, C. D., Hooton, T. M., Collier, A. C., & Lukehart, S. A. (1987). Neurologic Relapse after Benzathine Penicillin Therapy for Secondary Syphilis in a Patient with HIV Infection. New England Journal of Medicine. https://doi.org/10.1056/nejm198706183162507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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