The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Familial Occurrence of Accessory Atrioventricular Pathways (Preexcitation Syndrome)
Abstract
Accessory atrioventricular pathways, the anatomical structures responsible for the preexcitation syndromes, may result from a developmental failure to eradicate the remnants of the atrioventricular connections present during cardiogenesis. To study whether preexcitation syndromes could also be transmitted genetically, we determined the prevalence of preexcitation in the first-degree relatives of 383 of 456 consecutive patients (84 percent) with electrophysiologically proved accessory pathways. We compared the observed prevalence of preexcitation among the 2343 first-degree relatives with the frequency reported in the general population (0.15 percent). For 13 of the 383 index patients (3.4 percent), accessory pathways were documented in one or more first-degree relatives. At least 13 of the 2343 relatives identified (0.55 percent) had preexcitation; this prevalence was significantly higher than that in the general population (P less than 0.0001). Identification of affected relatives may have been incomplete because clinical information was obtained only about symptomatic relatives. Patients with familial preexcitation have a higher incidence of multiple accessory pathways and possibly an increased risk of sudden cardiac death. Our data suggest a hereditary contribution to the development of accessory pathways in humans. The pattern of inheritance appears to be autosomal dominant.
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“In the general population, the prevalence of WPW pattern on surface ECG is from 0.15% to 0.25%, 304 increasing to 0.55% among first-degree relatives of affected patients.305”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [305]
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Cites
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90338-v · Cited by 7,153
Ventricular fibrillation in the Wolff-Parkinson-White syndrome
Klein, G. J., Bashore, T. M., Sellers, T. D., Pritchett, E. L. C., Smith, W. M., & Gallagher, J. J. (1979) · New England Journal of Medicine · doi:10.1056/nejm197911153012003 · Cited by 830
Electrocardiographic Findings in 122,043 Individuals
Hiss, R. G., & Lamb, L. E. (1962) · Circulation · doi:10.1161/01.cir.25.6.947 · Cited by 494
Smith, W., Gallagher, J. J., Kerr, C. R., Sealy, W. C., Kasell, J. H., Benson, D. W., Reiter, M. J., Sterba, R., & Grant, A. O. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90048-0 · Cited by 178
Hunter, A., Papp, C., & Parkinson, J. (1940) · Heart · doi:10.1136/hrt.2.2.107 · Cited by 75
The electrocardiographic syndrome of short P-R interval and broad QRS complexes
Hejtmancik, M. R., & Herrmann, G. R. (1957) · American Heart Journal · doi:10.1016/0002-8703(57)90425-8 · Cited by 72
DEVELOPMENT AND HEALING OF RICKETS IN INTRAMEMBRANOUS BONE
BAILIE, J. M., & Irving, J. T. (1955) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1955.tb16276.x · Cited by 50
Gillette, P. C., Freed, D., & McNamara, D. G. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80511-3 · Cited by 29
Pre-excitation syndrome: Facts and theories
(1980) · American Heart Journal · doi:10.1016/0002-8703(80)90298-7 · Cited by 24
Developmental Aspects and Natural History of Preexcitation Syndromes
Dunnigan, A. (1986) · Springer eBooks · doi:10.1007/978-1-4684-7526-5_2 · Cited by 21
Vectorial interpretation of the ventricular complex in Wolff-Parkinson-White syndrome
Tranchesi, J., Guimarães, A. C., Teixeira, V., & Pileggi, F. (1959) · The American Journal of Cardiology · doi:10.1016/0002-9149(59)90046-3 · Cited by 21
An electrocardiographic study of 17,000 fit, young Royal Canadian Air Force aircrew applicants∗
Manning, G. W. (1960) · The American Journal of Cardiology · doi:10.1016/0002-9149(60)90037-0 · Cited by 20
LAHDENSUU, S. (1947) · Acta Paediatrica · doi:10.1111/j.1651-2227.1947.tb03685.x · Cited by 13
Wolff, Parkinson and White's Syndrome
Mortensen, V., NIELSEN, A. L., & ESKILDSEN, P. (1944) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1944.tb17824.x · Cited by 10
The Wolff-Parkinson-White pattern in health aircrew.
Davidoff, R., Schamroth, C., & Myburgh, D. P. (1981) · PubMed · Cited by 9
An unusual variant of familial preexcitation
Vidaillet, H. J., Jr., Burton, C. S., Ramirez, N. M., GILBERT, M. R., Behar, V. S., Hackel, D. B., & German, L. D. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90822-8 · Cited by 7
Landtman, B. (1947) · Acta Paediatrica · doi:10.1111/j.1651-2227.1947.tb06769.x · Cited by 7
Disturbances of Cardiac Rhythm
Dunnigan, A., & Benson, D. W. (1987) · Springer eBooks · doi:10.1007/978-1-4613-2305-1_7 · Cited by 2
Research works printed but not linked: 8
- Zipes DP. Specific arrhythmias: diagnosis and treatment. In: Braunwald E, ed. Heart disease. 2nd ed. Philadelphia: W.B. Saunders, 1984:718.
- Critelli, 1981, G Ital Cardiol, 11, 1883
- Joseph, 1958, Semaine Hopitaux Paris, 34, 552
- Kupatz, 1956, Neue Oesterr Zschr Kinderh, 1, 59
- Nasser, 1971, J Indiana State Med Assoc, 64, 111
- Tamm, 1956, Helv Paediatr Acta, 11, 78
- Öhnell, 1944, Acta Med Scand [Suppl], 152, 1
- Warner, 1958, Clin Res, 6, 18
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Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomström‐Lundqvist, C., Calkins, H. G., Corrado, D., Deftereos, S. G., Diller, G., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz467 · Cited by 1,312
Blomström‐Lundqvist, C., Scheinman, M. M., Aliot, E., Alpert, J. S., Calkins, H. G., Camm, A. J., Campbell, W. B., Haines, D. E., Kück, K., Lerman, B. B., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.013 · Cited by 684
Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · EP Europace · doi:10.1093/europace/euac030 · Cited by 421
Cohen, M. I., Triedman, J. K., Cannon, B. C., Davis, A. M., Drago, F., Janoušek, J., Klein, G. J., Law, I. H., Morady, F., Paul, T., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.03.050 · Cited by 379
Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.03.1225 · Cited by 287
Metadata
- Authors
- Vidaillet, H. J., Pressley, J. C., Henke, E., Harrell, F. E., & German, L. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-07-09
- Volume
- 317
- Issue
- 2
- Pages
- 65-69
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335789543
- Cited by
- 147
- References
- 18
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 1 · 2013: 7 · 2012: 6
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (HS-03834)
- National Heart, Lung, and Blood Institute (HL 07063, HL17670)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Keywords
- accessory pathway, preexcitation syndrome, Wolff-Parkinson-White syndrome, familial occurrence, genetic transmission, autosomal dominant inheritance, first-degree relatives, multiple accessory pathways, sudden cardiac death, heart development
- MeSH terms
- Death, Sudden, Female, Heart Conduction System, Heart Diseases, Humans, Male, Pedigree, Pre-Excitation Syndromes, Sex Factors, United States
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