The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias
Abstract
ACTIVATION of cellular oncogenes by chromosomal translocation has been strongly implicated in the pathogenesis of several cancers. One of the most striking examples of this phenomenon occurs in leukemias involving the Philadelphia (Ph1) chromosome. The Ph1 chromosome is a shortened chromosome 22 that arises from a reciprocal translocation, t(9;22)(q34;q11).1 , 2 This cytogenetic aberration occurs in the majority of patients with chronic myelogenous leukemia (CML)3 and in a much smaller proportion of patients with acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML).4 , 5 The Ph1 translocation results in transposition of the cellular abl (c-abl) gene from its usual residence . . .
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Cites
ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291
A minute chromosome in human chronic granulocytic leukemia
Nowell̀, P. C. (1960) · Science · Cited by 2,269
Hunter, T., & Cooper, J. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004341 · Cited by 2,107
Dalla-Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,773
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
Shtivelman, E., Lifshitz, B., Gale, R. P., & Canaani, E. (1985) · Nature · doi:10.1038/315550a0 · Cited by 1,611
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
GROFFEN, J., STEPHENSON, J., HEISTERKAMP, N., DEKLEIN, A., BARTRAM, C., & GROSVELD, G. (1984) · Cell · doi:10.1016/0092-8674(84)90077-1 · Cited by 1,599
Konopka, J. B., Watanabe, S. M., & Witte, O. N. (1984) · Cell · doi:10.1016/0092-8674(84)90438-0 · Cited by 892
Structural organization of the bcr gene and its role in the Ph′ translocation
Heisterkamp, N., Stam, K., Groffen, J., de Klein, A., & Grosveld, G. (1985) · Nature · doi:10.1038/315758a0 · Cited by 882
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Heisterkamp, N., Stephenson, J. R., Groffen, J., Hansen, P. F., de Klein, A., Bartram, C. R., & Grosveld, G. (1983) · Nature · doi:10.1038/306239a0 · Cited by 842
Cited by
Daley, G. Q., Van Etten, R. A., & Baltimore, D. (1990) · Science · doi:10.1126/science.2406902 · Cited by 1,756
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
Ren, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1567 · Cited by 878
Miyoshi, H., Shimizu, K., Kozu, T., Maseki, N., Kaneko, Y., & Ohki, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10431 · Cited by 872
Druker, B. J., & Lydon, N. B. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9083 · Cited by 707
Pendergast, A. M., Quilliam, L. A., Cripe, L. D., Bassing, C. H., Dai, Z., Li, N., Batzer, A., Rabun, K. M., Der, C. J., Schlessinger, J., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90689-n · Cited by 659
Metadata
- Authors
- Epstein, F. H., Kurzrock, R., Gutterman, J. U., & Talpaz, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-10-13
- Volume
- 319
- Issue
- 15
- Pages
- 990-998
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2339475636
- Cited by
- 837
- References
- 61
- FWCI
- 22.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Epstein, F. H., Kurzrock, R., Gutterman, J. U., & Talpaz, M. (1988). The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias. New England Journal of Medicine. https://doi.org/10.1056/nejm198810133191506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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