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Muscarinic Receptor Subtypes
Abstract
CHOLINERGIC neurons affect tissues by releasing the neurotransmitter acetylcholine, which stimulates acetylcholine receptors on the cell surface. These receptors are classified as nicotinic or muscarinic receptors on the basis of their response to the alkaloids nicotine and muscarine.1 The nicotinic receptors are widely distributed in tissues and mediate the actions of acetylcholine in the neurons of striated muscles, autonomic ganglia, and the central nervous system.2 Muscarinic receptors are key participants in many physiologic processes, such as nerve-to-nerve transmission, smooth-muscle contraction, and exocrine and endocrine secretion. Clinically, they have a major role in many pathologic processes. Muscarinic agonists and antagonists, popularly . . .
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Citations
Cited by
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function
Gilon, P., & Henquin, J.-C. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.5.0440 · Cited by 508
The Cholinergic Hypothesis of Neuropsychiatric Symptoms in Alzheimer's Disease
Cummings, J. L., & Back, C. (1998) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199821001-00009 · Cited by 274
Koglin, J., Böhm, M., von Scheidt, W., Stäblein, A., & Erdmann, E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90754-4 · Cited by 21
Metadata
- Authors
- Flier, J. S., Underhill, L. H., & Goyal, R. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-10-12
- Volume
- 321
- Issue
- 15
- Pages
- 1022-1029
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2091655143
- Cited by
- 239
- References
- 0
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Muscarinic Receptor Subtypes. https://app.cochat.ai/papers/10.1056/nejm198910123211506
- The paper
- Flier, J. S., Underhill, L. H., & Goyal, R. K. (1989). Muscarinic Receptor Subtypes. New England Journal of Medicine. https://doi.org/10.1056/nejm198910123211506
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
