CoChat
Sign Up
Cited by 345Vitamin D Research StudiesParathyroid Disorders and TreatmentsBone health and osteoporosis research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effect of Vitamin D Intake on Seasonal Variations in Parathyroid Hormone Secretion in Postmenopausal Women

Krall, Elizabeth A., Sahyoun, Nadine, Tannenbaum, Saul, Dallal, Gerard E., Dawson-Hughes, Bess·1989·New England Journal of Medicine
DOI 10.1056/nejm198912283212602
Open this paper in CoChat — free account

Abstract

Vitamin D intake should be sufficient to maintain calcium absorption and prevent increased parathyroid secretion throughout the year. To determine the level of intake that achieved the latter in elderly women, we studied the interrelations among vitamin D intake, serum 25-hydroxyvitamin D (25(OH)D) levels, and parathyroid hormone concentrations in a cross-sectional study of 333 healthy, white, postmenopausal women with low median calcium (408 mg a day) and vitamin D (112 IU a day) intakes who lived in Massachusetts. The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake. In women whose estimated intake of vitamin D was less than or equal to 220 IU a day, the mean (+/- SD) serum parathyroid hormone values were lowest in those studied between August and October (30 +/- 11 ng per liter; n = 72) and highest in those studied between March and May (37 +/- 16 ng per liter; n = 54); the respective serum 25(OH)D levels were 93 +/- 32 and 63 +/- 21 nmol per liter. At vitamin D intakes of more than 220 IU a day, the mean serum parathyroid hormone and 25(OH)D levels did not vary with the season. The correlation between vitamin D intake and serum 25(OH)D concentration, although significant in all women (r = 0.29; P less than 0.001), was highest in those studied between March and May (r = 0.65; P less than 0.001) and lowest in those studied between August and October (r = 0.13; P greater than 0.10). The estimated serum 25(OH)D level associated with a vitamin D intake of 220 IU a day between March and May was 95 nmol per liter. Mean serum calcium values were similar at all times in both groups. We conclude that the dietary intake of more than 220 IU of vitamin D a day by postmenopausal women in Massachusetts may be sufficient to maintain constant serum 25(OH)D and parathyroid hormone concentrations throughout the year. Such an intake prevents a seasonal increase in parathyroid hormone secretion, with its possible deleterious skeletal effects.

Overview

Integrity signals

Registry

Crossref · 10.1056/nejm198912283212602

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 37 references

Research works printed but not linked: 4

  1. Meller, 1986, Isr J Med Sci, 22, 8
  2. Parfitt AM. Accelerated cortical bone loss: primary and secondary hyperparathyroidism. In: Uhthoff H, Stahl E, eds. Current concepts of bone fragility. Berlin: Springer-Verlag, 1986:279–85.
  3. Peacock M, Selby PL, Francis RM, Brown WB, Hordon L. Vitamin D deficiency, insufficiency, sufficiency and intoxication: what do they mean? In: Norman AW, Schaefer K, Grigoleit H-G, von Herrath D, eds. Vitamin D: chemical, biochemical, and clinical update: sixth workshop on vitamin D. New York: Walter de Gruyter, 1985:569–70.
  4. Barragry, 1978, Clin Sci Mol Med, 55, 213

Cited by

Sorted by citations

Items 201–300 of 345

Related

See all

Metadata

Authors
Krall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G. E., & Dawson-Hughes, B.
Affiliations
Tufts University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1989-12-28
Volume
321
Issue
26
Pages
1777-1783
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198912283212602
OpenAlex
W1987770924
Cited by
345
References
37
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 13 · 2012: 3
FWCI
8.70
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
vitamin D intake, parathyroid hormone, 25-hydroxyvitamin D, seasonal variation, postmenopausal women, serum calcium, vitamin D sufficiency, parathyroid hormone secretion, bone health, older women, low calcium intake, vitamin D deficiency prevention
MeSH terms
Calcium, Calcium, Dietary, Cross-Sectional Studies, Dose-Response Relationship, Drug, Female, Humans, Hydroxycholecalciferols, Massachusetts, Menopause, Middle Aged, Parathyroid Hormone, Seasons, Vitamin D

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review