The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic Linkage of a Polymorphism in the Type II Procollagen Gene (COL2A1) to Primary Osteoarthritis Associated with Mild Chondrodysplasia
Abstract
OSTEOARTHRITIS is a clinically heterogeneous disease characterized by a progressive degeneration of the articular cartilages of both weight-bearing and non-weight-bearing joints.1 Some forms of the disease are due to environmental or systemic events, such as trauma, infections, and metabolic disorders, but most patients have primary osteoarthritis for which there is no identifiable cause. At the same time, the inheritance of the disease in some families is well documented.2 , 3 We analyzed restriction-fragmentlength polymorphisms (RFLPs) to show that one allele of the gene for Type II procollagen (COL2A1), the precursor of the major protein of cartilage,4 , 5 is inherited with a precocious form . . .
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Citations
Cites
PERSISTENT JOINT LAXITY AND CONGENITAL DISLOCATION OF THE HIP
Carter, C., & Wilkinson, J. (1964) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.46b1.40 · Cited by 590
Cited by
Etiopathogenesis of Osteoarthritis
Brandt, K. D., Dieppe, P., & Radin, E. L. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.05.011 · Cited by 417
The type II collagenopathies: A spectrum of chondrodysplasias
Spranger, J., Winterpacht, A., & Zabel, B. (1994) · European Journal of Pediatrics · doi:10.1007/bf01959208 · Cited by 261
From Structure to Phenotype: Impact of Collagen Alterations on Human Health
Arseni, L., Lombardi, A., & Orioli, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051407 · Cited by 186
“Several cases have been reported, included family members over various generations [95,100,101].”
Background
Metadata
- Authors
- Knowlton, R. G., Katzenstein, P. L., Moskowitz, R. W., Weaver, E. J., Malemud, C. J., Pathria, M. N., Jimenez, S. A., & Prockop, D. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-02-22
- Volume
- 322
- Issue
- 8
- Pages
- 526-530
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327082194
- Cited by
- 186
- References
- 1
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetic Linkage of a Polymorphism in the Type II Procollagen Gene (COL2A1) to Primary Osteoarthritis Associated with Mild Chondrodysplasia. https://app.cochat.ai/papers/10.1056/nejm199002223220807
- The paper
- Knowlton, R. G., Katzenstein, P. L., Moskowitz, R. W., Weaver, E. J., Malemud, C. J., Pathria, M. N., Jimenez, S. A., & Prockop, D. J. (1990). Genetic Linkage of a Polymorphism in the Type II Procollagen Gene (COL2A1) to Primary Osteoarthritis Associated with Mild Chondrodysplasia. New England Journal of Medicine. https://doi.org/10.1056/nejm199002223220807
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
