Phototherapy and photochemotherapy
Abstract
Human diseases have been treated with the sun's rays since antiquity.1 It is a form of phototherapy, which is defined as the direct use of nonionizing radiation to treat disease. The use of ultraviolet B radiation (290 to 320 nm) in the treatment of psoriasis, with or without the additive effect of coal-tar products, is an excellent example of phototherapy. The effects of ultraviolet B rays on this disease appear to result from a direct inhibition of DNA synthesis and mitosis in the hyperproliferating epidermal cells that are characteristic of psoriasis.2 However, direct effects on dermal blood vessels and infiltrating . . .
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Psoralens directly interact with RNA, proteins and other cellular components and indirectly modify them via ROS.
“Psoralens directly interact with RNA, proteins and other cellular components and indirectly modify them via ROS [112].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [112]
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Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
- Authors
- Epstein, J. H.
- Corresponding author
- Epstein, John H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-04-19
- Volume
- 322
- Issue
- 16
- Pages
- 1149-1151
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1997801494
- Cited by
- 56
- References
- 0
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- phototherapy, photochemotherapy, UV-B radiation, psoriasis, coal tar, DNA synthesis inhibition, epidermal proliferation, non-ionizing radiation, history of phototherapy
- MeSH terms
- Carcinoma, Squamous Cell, Genital Neoplasms, Male, Humans, Male, Neoplasms, Radiation-Induced, Psoriasis, PUVA Therapy, Ultraviolet Therapy
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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