Heart Disease and the Eosinophil
Abstract
In 1936, Löffler first recognized the association of a distinctive form of severe heart failure with marked eosinophilia.1 Although the clinical picture mimicked that of constrictive pericarditis, pathological examination revealed a grossly thickened endomyocardium with intraventricular mural thrombosis — a clinical syndrome we now recognize as a restrictive cardiomyopathy. Since that description, a number of diverse terms, including "eosinophilic collagen vascular disease," "eosinophilic leukemia," and "idiopathic eosinophilia," have been used to describe a disease characterized by marked eosinophilia, the infiltration of multiple organs by mature eosinophils, and multiple-organ-system dysfunction.The current thinking is that all these entities are part of . . .
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Eosinophils likely play a pathogenic role in eosinophilic myocarditis, contributing to inflammation and subsequent fibrosis and heart failure.
“Eosinophils likely play a pathogenic role in eosinophilic myocarditis, contributing to inflammation and its subsequent consequences such as fibrosis and heart failure conditions.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [205]
Cytokines and granule contents released by eosinophils including major basic protein are highly proinflammatory and cytotoxic in the heart.
“The cytokines and granule contents released by eosinophils including major MBP (major basic protein) are known to be highly proinflammatory and cytotoxic in the heart.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [205]
Cites
The cardiovascular manifestations of the hypereosinophilic syndrome
Parrillo, J. E., Borer, J. S., Henry, W. L., Wolff, S. M., & Fauci, A. S. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90227-4 · Cited by 314 · see citing works
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Parrillo, J. E.
- Corresponding author
- Parrillo, Joseph E.
- ORCID
- Parrillo, Joseph E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-11-29
- Volume
- 323
- Issue
- 22
- Pages
- 1560-1561
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1977190128
- Cited by
- 83
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Keywords
- eosinophilia, heart disease, eosinophilic cardiomyopathy, restrictive cardiomyopathy, eosinophilic leukemia, eosinophil infiltration, constrictive pericarditis, heart failure
- MeSH terms
- Eosinophils, Humans, Cardiomyopathies, Myocarditis
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