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Fluoroquinolone Antimicrobial Agents
Abstract
THE introduction of fluoroquinolone antimicrobial agents (Fig. 1) into clinical use is an important recent advance.1-3 These drugs, also called quinolones, include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, and pefloxacin. Of these, norfloxacin, ciprofloxacin, and ofloxacin have been approved for use in the United States. Quinolones are orally absorbed, are potent in vitro against a broad spectrum of bacterial species, and have favorable pharmacokinetic properties. We shall evaluate here the current status of the quinolones, considering mechanisms of action and resistance, activity in vitro, pharmacokinetics, clinical efficacy, adverse effects, and clinical uses. A discussion of the structure-activity relations of the quinolones . . .
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Citations
Cited by
Quinolone-Resistant Campylobacter jejuni Infections in Minnesota, 1992–1998
Smith, K. E., Besser, J. M., Hedberg, C. W., Leano, F. T., Bender, J. B., Wicklund, J. H., Johnson, B. P., Moore, K. A., & Osterholm, M. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905203402001 · Cited by 666
Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
Burden, D. A., & Osheroff, N. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00132-8 · Cited by 503
Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.
Froelich-Ammon, S. J., Patchan, M. W., Osheroff, N., & Thompson, R. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14998 · Cited by 137
Metadata
- Authors
- Hooper, D. C., & Wolfson, J. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-02-07
- Volume
- 324
- Issue
- 6
- Pages
- 384-394
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2319438985
- Cited by
- 548
- References
- 0
- FWCI
- 49.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hooper, D. C., & Wolfson, J. S. (1991). Fluoroquinolone Antimicrobial Agents. New England Journal of Medicine. https://doi.org/10.1056/nejm199102073240606
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