Heparin
Abstract
HEPARIN was discovered in 1916 by McLean,1 who as a medical student was looking for a coagulant in the liver. In 1939, Brinkhous and associates2 demonstrated that the anticoagulant activity of heparin requires a plasma cofactor (that they called heparin cofactor). In 1968, Abildgaard3 renamed the substance antithrombin III, and the mechanism of interaction between antithrombin III and heparin was elucidated in the 1970s.4 5 6 7 The active center serine of thrombin and other coagulation enzymes is inhibited by an arginine reactive center of the antithrombin III molecule. Heparin binds to lysine sites on antithrombin III and produces a conformational change at . . .
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In clinical settings, anticoagulants, most commonly heparin, are routinely given to prevent surface-induced thrombosis during cardiopulmonary bypass, hemodialysis, and angioplasty.
“In a clinical setting, in order to prevent surface-induced thrombosis during cardiopulmonary bypass, hemodialysis, and angioplasty, anticoagulants are routinely administered, the most commonly used one being heparin.2,21”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [21]
The citation lists haven’t been fetched yet
References 123 · Cited by 830
- Authors
- Oates, J. A., Wood, A. J. J., & Hirsh, J.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Hirsh, Jack
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-05-30
- Volume
- 324
- Issue
- 22
- Pages
- 1565-1574
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4205312708
- Cited by
- 830
- References
- 123
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 15 · 2023: 13 · 2022: 8 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 8 · 2013: 13 · 2012: 15
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- heparin, antithrombin III, anticoagulant activity, heparin cofactor, thrombin inhibition, serine protease inhibition, lysine binding site, conformational change
- MeSH terms
- Coronary Disease, Female, Heparin, Humans, Pregnancy, Thromboembolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
