The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Reduction of Solar Keratoses by Regular Sunscreen Use
Open accessAbstract
BACKGROUND: The incidence of and mortality from skin cancer are increasing in many countries. In view of the added concern about ozone depletion, many organizations are promoting the regular use of sunscreens to prevent skin cancer, despite the absence of evidence that these products have this effect. Solar (actinic) keratosis is a precursor of squamous-cell carcinoma of the skin. METHODS: We conducted a randomized, controlled trial of the effect on solar keratoses of daily use of a broad-spectrum sunscreen cream with a sun-protection factor of 17 in 588 people 40 years of age or older in Australia during one summer (September 1991 to March 1992). The subjects applied either a sunscreen cream or the base cream minus the active ingredients of the sunscreen to the head, neck, forearms, and hands. RESULTS: The mean number of solar keratoses increased by 1.0 per subject in the base-cream group and decreased by 0.6 in the sunscreen group (difference, 1.53; 95 percent confidence interval, 0.81 to 2.25). The sunscreen group had fewer new lesions (rate ratio, 0.62; 95 percent confidence interval, 0.54 to 0.71) and more remissions (odds ratio, 1.53; 95 percent confidence interval, 1.29 to 1.80) than the base-cream group. There was a dose-response relation: the amount of sunscreen cream used was related to both the development of new lesions and the remission of existing ones. CONCLUSIONS: Regular use of sunscreens prevents the development of solar keratoses and, by implication, possibly reduces the risk of skin cancer in the long-term.
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Cites
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Cancer Incidence in Five Continents
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McCullagh, P., & Nelder, J. A. (1983) · Springer eBooks · doi:10.1007/978-1-4899-3244-0 · Cited by 1,980
Department of Health and Human Services
(2002) · Handbook of Research Design & Social Measurement · doi:10.4135/9781412984386.n104 · Cited by 1,032
MALIGNANT TRANSFORMATION OF SOLAR KERATOSES TO SQUAMOUS CELL CARCINOMA
Marks, R., Rennie, G., & Selwood, T. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91658-3 · Cited by 658
Self-citationNonmelanoma Cancers of the Skin
Preston, D. S., & Stern, R. S. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212033272307 · Cited by 540
Spontaneous remission of solar keratoses: the case for conservative management
MARKS, R., FOLEY, P., GOODMAN, G., HAGE, B. H., & SELWOOD, T. S. (1986) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1986.tb06644.x · Cited by 319
Self-citationTrends in non‐melanocytic skin cancer treated in Australia: The second national survey
Marks, R., Staples, M., & Giles, G. G. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530410 · Cited by 270
Self-citationEpidemiology of Malignant Melanoma: Intermittent or Total Accumulated Exposure to the Sun?
ARMSTRONG, B. K. (1988) · The Journal of Dermatologic Surgery and Oncology · doi:10.1111/j.1524-4725.1988.tb03588.x · Cited by 233
The Relationship of Basal Cell Carcinomas and Squamous Cell Carcinomas to Solar Keratoses
Marks, R. (1988) · Archives of Dermatology · doi:10.1001/archderm.124.7.1039 · Cited by 173
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Cited by
The epidemiology of UV induced skin cancer
Armstrong, B. K., & Kricker, A. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00198-1 · Cited by 1,811
Green, A., Williams, G., Nèale, R., Hart, V., Leslie, D., Parsons, P., Marks, G. C., Gaffney, P., Battistutta, D., Frost, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12168-2 · Cited by 976
A Phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention
Chen, A. C., Martin, A. J., Choy, B., Fernández-Peñas, P., Dalziell, R. A., McKenzie, C. A., Scolyer, R. A., Dhillon, H. M., Vardy, J. L., Kricker, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1506197 · Cited by 648
Krause, M., Klit, A., Blomberg Jensen, M., Søeborg, T., Frederiksen, H., Schlumpf, M., Lichtensteiger, W., Skakkebaek, N. E., & Drzewiecki, K. T. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01280.x · Cited by 461
A review of skin ageing and its medical therapy
GILCHREST, B. A. (1996) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1996.d01-1088.x · Cited by 444
Metadata
- Authors
- Thompson, S. C., Jolley, D., & Marks, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1993-10-14
- Volume
- 329
- Issue
- 16
- Pages
- 1147-1151
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2322825431
- Cited by
- 773
- References
- 18
- FWCI
- 26.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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