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Cited by 169Nonmelanoma Skin Cancer StudiesSkin Protection and AgingHead and Neck Cancer Studies

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Effect of a Low-Fat Diet on the Incidence of Actinic Keratosis

Black, Homer S., Herd, J. Alan, Goldberg, Leonard H., Wolf, John E., Thornby, John I., Rosen, Theodore, Bruce, Suzanne, Tschen, Jaime A., Foreyt, John P., Scott, Lynne W., Jaax, Suzanne, Andrews, Kelly·1994·New England Journal of Medicine
DOI 10.1056/nejm199405053301804
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Abstract

Background Actinic keratoses are premalignant lesions and are a sensitive and important manifestation of sun-induced skin damage. Studies in animals have shown that dietary fat influences the incidence of sun-induced skin cancer, but the effect of diet on the incidence of actinic keratosis in humans is not known. Methods We randomly assigned 76 patients with nonmelanoma skin cancer either to continue their usual diet (control group) or to eat a diet with 20 percent of total caloric intake as fat (dietary-intervention group). For 24 months, the patients were examined for the presence of new actinic keratoses by physicians unaware of their assigned diets. Results At base line, the mean (+/- SD) percentage of caloric intake as fat was 40 +/- 4 percent in the control group and 39 +/- 3 percent in the dietary-intervention group. After 4 months of dietary therapy the percentage of calories as fat had decreased to 21 percent in the dietary-intervention group, and it remained below this level throughout the 24-month study period. The percentage of calories as fat in the control group did not fall below 36 percent at any time. The cumulative number of new actinic keratoses per patient from months 4 through 24 was 10 +/- 13 in the control group and 3 +/- 7 in the dietary-intervention group (P = 0.001). Conclusions In patients with a history of nonmelanoma skin cancer, a low-fat diet reduces the incidence of actinic keratosis.

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Research works printed but not linked: 17

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Metadata

Authors
Black, H. S., Herd, J. A., Goldberg, L. H., Wolf, J. E., Thornby, J. I., Rosen, T., Bruce, S., Tschen, J. A., Foreyt, J. P., Scott, L. W., Jaax, S., & Andrews, K.
Affiliations
Baylor College of Medicine (US)
ORCID
Herd, J. Alan
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1994-05-05
Volume
330
Issue
18
Pages
1272-1275
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199405053301804
OpenAlex
W2322868828
Cited by
169
References
20
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 10
FWCI
8.59
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca044383-08)
  • National Cancer Institute (CA-44383)
Topics
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords
actinic keratosis, low-fat diet, dietary fat, non-melanoma skin cancer, premalignant skin lesions, dietary intervention, skin cancer prevention
MeSH terms
Basal Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Dietary Fats, Female, Follow-Up Studies, Humans, Keratosis, Male, Middle Aged, Precancerous Conditions, Risk Factors, Skin Neoplasms, Sunlight, Incidence, Confidence Intervals, Logistic Models, Odds Ratio

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