Cited by 203Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersElectrolyte and hormonal disorders

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Hypopituitarism

Vance, Mary Lee·1994·New England Journal of Medicine

DOI 10.1056/nejm199406093302306

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Abstract

Hypopituitarism may be either partial or complete and may result from either pituitary or hypothalamic disease. Its clinical manifestations vary, depending on the extent and severity of the pituitary hormone deficiency. Thus, a patient may present in extremis with acute adrenal insufficiency or profound hypothyroidism, with symptoms indicating a pituitary mass lesion, or with nonspecific symptoms of fatigue and malaise.Most of the hypothalamic-pituitary-target-organ axes are tightly coordinated systems in which hormonal signals from the hypothalamus stimulate or inhibit secretion of anterior pituitary hormones; these hormones, in turn, act on specific organs. These axes are frequently described as closed-loop or . . .

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Duan, S.-L., Du, L.-K., & Zheng, L. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i22.949
Congenital hypopituitarism: A case report
Mali, M. S., Vellore, K. P., Shilpa, G., & Kumar, C. S. (2021) · Journal of Oral Medicine Oral Surgery Oral Pathology and Oral Radiology · doi:10.18231/j.jooo.2021.025
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Andrade, T. G., Ramos, A. M., Marinho, S. P. D. A., Furtado, G. P., Andrade, T. G., & Barbosa, O. A. (2024) · Revista Científica do Hospital e Maternidade José Martiniano Alencar · doi:10.54257/2965-0585.v4.i1.72
Hemorrhagic PitNets Are Associated with Previous Vascular Events and Result in Worse Endocrine Outcome
Hounchonou, H. F., Lang, J. M., Döring, K., Terkamp, C., Leitolf, H., Al–Afif, S., Hermann, E. J., Hartmann, C. J., & Krauss, J. K. (2024) · Cancers · doi:10.3390/cancers16234105
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QUABBE, H.-J., & Plöckinger, U. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-217-3_17
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Herodes, M., Leonardi, C., & Garcia, J. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-89650-7_25
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Anyim, O. B., Young, E. E., Emokah, A. P., Okafor, C. I., Nwatu, C. B., Meka, I. A., Onuzulike, A. L., & Chidiobi, V. E. (2025) · International Journal of Medicine and Health Development · doi:10.4103/ijmh.ijmh_100_24
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Two Decades of Endocrine Silence: Severe Hyponatremia Presenting as Late-Onset Sheehan Syndrome
Fontalvo, A. S., la Rosa, S. M. C. D., Arrieta, J., Perez, R. E. C., & Arrieta, L. A. R. (2026) · Cureus · doi:10.7759/cureus.113377

Authors: Vance, M. L.
Affiliations: University of Virginia Health System (US)
Corresponding author: Vance, Mary Lee
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1994-06-09
Volume: 330
Issue: 23
Pages: 1651-1662
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199406093302306
OpenAlex: W4249920490
Cited by: 203
References: 52
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 8
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords: hypopituitarism, pituitary hormone deficiency, hypothalamic disease, pituitary disorders, adrenal insufficiency, hypothyroidism, anterior pituitary hormones
MeSH terms: Humans, Hypopituitarism

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