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Hypoxia of the Renal Medulla — Its Implications for Disease
Abstract
In land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry environment. Water conservation is enhanced by the renal medulla, which concentrates the urine to a level up to four times the osmolality of plasma. To produce this unique gradient of osmolality, the medulla has a countercurrent system of vessels and tubules that dictates active reabsorption of sodium in a milieu poor in oxygen (Figure 1).1 In this review, we describe how hypoxia of the medulla may relate to susceptibility to acute and chronic renal injury.The Renal Medullary Concentrating Mechanism as . . .
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Cited by
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Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246
Mechanisms of sodium pump regulation
Therien, A. G., & Blostein, R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c541 · Cited by 765
Tögel, F., Weiss, K., Yang, Y., Hu, Z., Zhang, P., & Westenfelder, C. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00339.2006 · Cited by 641
Calzavacca, P., Licari, E., & Bellomo, R. (2010) · Surgical Intensive Care Medicine · doi:10.1007/978-0-387-77893-8_38 · Cited by 533
Vallon, V., Mühlbauer, B., & Osswald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 448
Metadata
- Authors
- Brezis, M., & Rosen, S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-03-09
- Volume
- 332
- Issue
- 10
- Pages
- 647-655
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1982628508
- Cited by
- 1,222
- References
- 0
- FWCI
- 24.92
- Type
- journal article
- Language
- en
- Open access
- closed
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