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Chronic Lymphocytic Leukemia
Abstract
Chronic lymphocytic leukemia (CLL), the most frequent form of leukemia in Western countries, is characterized by the clonal proliferation and accumulation of neoplastic B lymphocytes in the blood, bone marrow, lymph nodes, and spleen. The median age of patients at diagnosis is 65 years, with only 10 to 15 percent under 50 years of age. In most series, more men than women are affected. The course of the disease is variable. Whereas some patients with CLL have a normal life span, others die within five years after diagnosis. During the past few years, important advances have been made in the . . .
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Cited by
Chiorazzi, N., Rai, K. R., & Ferrarini, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041720 · Cited by 1,296
Crespo, M., Bosch, F., Villamor, N., Bellosillo, B., Colomer, D., Rozman, M., Marcé, S., López-Guillermo, A., Campo, E., & Montserrat, E. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa023143 · Cited by 1,055
Self-citationZAP-70 expression and prognosis in chronic lymphocytic leukaemia.
Orchard, J. A., Ibbotson, R. E., Davis, Z., Wiestner, A., Rosenwald, A., Thomas, P. W., Hamblin, T. J., Staudt, L. M., & Oscier, D. G. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15260-9 · Cited by 448
B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather
Caligaris-Cappio, F., & Hamblin, T. J. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.1.399 · Cited by 321
STAT signaling in the pathogenesis and treatment of leukemias
Lin, T. S., Mahajan, S., & Frank, D. A. (2000) · Oncogene · doi:10.1038/sj.onc.1203486 · Cited by 205
Metadata
- Authors
- Rozman, C., & Montserrat, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-10-19
- Volume
- 333
- Issue
- 16
- Pages
- 1052-1057
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2323490326
- Cited by
- 791
- References
- 0
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rozman, C., & Montserrat, E. (1995). Chronic Lymphocytic Leukemia. New England Journal of Medicine. https://doi.org/10.1056/nejm199510193331606
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
