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Octreotide

Open access
Lamberts, Steven W.J., van der Lely, Aart-Jan, de Herder, Wouter W., Hofland, Leo J.·1996·New England Journal of Medicine

Abstract

A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats.1 This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids.2 Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion.3 Today, somatostatin is best regarded as a phylogenetically ancient, multigene family of peptides with two important bioactive products: somatostatin-14 and somatostatin-28, the latter a congener of somatostatin-14 extended at the N-terminal.3,4 Like other peptide . . .

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Metadata

Authors
Lamberts, S. W. J., van der Lely, A.-J., de Herder, W. W., & Hofland, L. J.
Venue
New England Journal of Medicine
Published
1996-01-25
Volume
334
Issue
4
Pages
246-254
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4250058955
Cited by
1,001
References
0
FWCI
30.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Octreotide. https://app.cochat.ai/papers/10.1056/nejm199601253340408
The paper
Lamberts, S. W. J., van der Lely, A.-J., de Herder, W. W., & Hofland, L. J. (1996). Octreotide. New England Journal of Medicine. https://doi.org/10.1056/nejm199601253340408

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.