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Adenoviruses as Gene-Delivery Vehicles
Abstract
For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a special case of drug delivery in which the therapeutic gene constitutes the drug. But the relevance of traditional drug development to technological developments in gene therapy is questionable. Recombinant genes that can independently express a therapeutic RNA or protein are extraordinarily large and polar molecules — 10,000 times larger than traditional pharmaceutical agents. Moreover, the administration of genes as therapy requires vehicles —so-called vectors — that encapsulate the gene and . . .
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Cited by
Immune responses to adenovirus and adeno-associated virus in humans
Chirmule, N., Propert, K. J., Magosin, S. A., Qian, Y., Qian, R., & Wilson, J. M. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300994 · Cited by 684
Self-citationCoronary in-stent restenosis: Current status and future strategies
Lowe, H. C., Oesterle, S. N., & Khachigian, L. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01742-9 · Cited by 414
Dicks, M. D. J., Spencer, A. J., Edwards, N. J., Wadell, G., Bojang, K., Gilbert, S. C., Hill, A. V. S., & Cottingham, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040385 · Cited by 384
Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis
Leopold, P. L., Kreitzer, G., Miyazawa, N., Rempel, S., Pfister, K. K., Rodriguez-Boulan, E., & Crystal, R. G. (2000) · Human Gene Therapy · doi:10.1089/10430340050016238 · Cited by 254
Sato, N., Leopold, P. L., & Crystal, R. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7691 · Cited by 253
Metadata
- Authors
- Wilson, J. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-05-02
- Volume
- 334
- Issue
- 18
- Pages
- 1185-1187
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2313269464
- Cited by
- 476
- References
- 0
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
