The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Absence of Association or Genetic Linkage between the Angiotensin-Converting–Enzyme Gene and Left Ventricular Mass
Abstract
Background Homozygous carriers of the D allele of the angiotensin-converting–enzyme (ACE) gene have been reported to be at increased risk for various cardiovascular disorders, including left ventricular hypertrophy. We investigated the potential role of the ACE gene in influencing left ventricular mass. Methods Quantitative echocardiographic data and DNA samples were available for 2439 subjects from the Framingham Heart Study. ACE genotypes were determined by an assay based on the polymerase chain reaction. (The D allele of the ACE gene contains a deletion, whereas the I [insertion] allele does not.) Left ventricular mass and the prevalence of left ventricular hypertrophy, adjusted for clinical covariates, were analyzed according to genotype. Genetic linkage between the ACE locus and left ventricular mass was evaluated by quantitative analysis of pairs of siblings. Results The ACE genotype was associated neither with left ventricular mass nor with the prevalence of left ventricular hypertrophy. Mean (±SE)...
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Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767
Self-citation(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
A new method for indexing left ventricular mass for differences in body size
Lauer, M. S., Anderson, K. M., Larson, M. G., & Levy, D. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90909-1 · Cited by 142
Cited by
Staessen, J. A., Wang, J. G., Ginocchio, G., Petrov, V., Saavedra, A. P., Soubrier, F., Vlietinck, R., & Fagard, R. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00059 · Cited by 385
Bernstein, K. E., Ong, F. S., Blackwell, W.-L. B., Shah, K. H., Giani, J. F., Gonzalez-Villalobos, R. A., Shen, X. Z., & Fuchs, S. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006809 · Cited by 324
Francke, S. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.24.2751 · Cited by 265
Dzau, V. J., Bernstein, K., Celermajer, D., Cohen, J., Dahlöf, B., Deanfield, J., Diez, J., Drexler, H., Ferrari, R., van Gilst, W., et al. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01878-1 · Cited by 259
The ACE Gene and Human Performance: 12 Years On
Puthucheary, Z., Skipworth, J. R. A., Rawal, J., Loosemore, M., Van Someren, K., & Montgomery, H. E. (2011) · Sports Medicine · doi:10.2165/11588720-000000000-00000 · Cited by 220
Metadata
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-10-03
- Volume
- 335
- Issue
- 14
- Pages
- 1070-1071
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2000294775
- Cited by
- 213
- References
- 6
- FWCI
- 22.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
