The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Paternity by Intrauterine Insemination with Sperm from a Man with 5α-Reductase-2 Deficiency
Open accessAbstract
Male pseudohermaphroditism results from the abnormal differentiation of male external genitalia in a genotypic male. One cause of male pseudohermaphroditism is a deficiency of 5α-reductase-2, the enzyme that converts testosterone to 5α-dihydrotestosterone in specific androgen-dependent target tissues.1–3 Males who are homozygous for the disorder usually present with pseudovaginal perineoscrotal hypospadias at birth. Most have distinct urethral and vaginal openings within a urogenital sinus and a clitoris-like phallus. Virilization occurs at puberty with phallic growth, rugation and pigmentation of the scrotum, and testicular descent.1–3 At this time, the voice deepens and muscle mass increases, with the development of a . . .
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“T and DHT also likely have differential roles and expression in various tissues, including in the prostate, skin, penis, and testicles, among others.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [29]
Citations
Cites
Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., & Sekiya, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2766 · Cited by 3,589
Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
Imperato-McGinley, J., Guerrero, L., Gautier, T., & Peterson, R. E. (1974) · Science · doi:10.1126/science.186.4170.1213 · Cited by 1,258
Self-citationFamilial Incomplete Male Pseudohermaphroditism, Type 2
Walsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., MacDonald, P. C., & Wilson, J. D. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410312911806 · Cited by 621
Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo
Siiteri, P. K., & Wilson, J. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-1-113 · Cited by 591
Imperato‐McGinley, J., Peterson, R. E., Gautier, T., & Sturla, E. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905313002201 · Cited by 444
Self-citationMale pseudohermaphroditism due to steroid 5α-reductase deficiency
Peterson, R. E., Imperato‐McGinley, J., Gautier, T., & Sturla, E. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90313-8 · Cited by 392
Self-citationNew method of evaluating sperm morphology with predictive value for human in vitro fertilization
Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., Veeck, L. L., Morshedi, M., & Brugo, S. (1987) · Urology · doi:10.1016/0090-4295(87)90246-9 · Cited by 260
Imperato‐McGinley, J., Sanchez, R. S., Spencer, J. R., Yee, B., & Vaughan, E. D. (1992) · Endocrinology · doi:10.1210/endo.131.3.1324152 · Cited by 246
Self-citationMale pseudohermaphroditism: The complexities of male phenotypic development
Imperato‐McGinley, J., & Peterson, R. E. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90175-3 · Cited by 156
Self-citationProstate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency
Imperato‐McGinley, J., Gautier, T., Zirinsky, K., Hom, T., Palomo, O., Stein, E. A., Vaughan, E. D., Markísz, J. A., de Arellano, E. R., & Kazam, E. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400866 · Cited by 154
Self-citationMendonca, B. B., Inácio, M., Costa, E. M. F., Arnhold, I. J. P., Silva, F. A. Q., Nicolau, W., BLOISE, W., Russell, D. W., & Wilson, J. D. (1996) · Medicine · doi:10.1097/00005792-199603000-00003 · Cited by 141
The Molecular Basis of Steroid 5α-Reductase Deficiency in a Large Dominican Kindred
Thigpen, A. E., Davis, D. L., Gautier, T., Imperato‐McGinley, J., & Russell, D. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210223271706 · Cited by 119
Self-citationImperato‐McGinley, J., Peterson, R. E., Leshin, M., Griffin, J. E., Cooper, G., DRAGHI, S., Berenyi, M. R., & Wilson, J. D. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-1-15 · Cited by 107
Self-citationThe Development of a Male Pseudohermaphroditic Rat Using an Inhibitor of the Enzyme 5α-Reductase*
Imperato‐McGinley, J., BINIENDA, Z. K., Arthur, A. B., Mininberg, D. T., Vaughan, E. D., & Quimby, F. W. (1985) · Endocrinology · doi:10.1210/endo-116-2-807 · Cited by 99
Self-citationThe Effect of a 5α-Reductase Inhibitor on Androgen Physiology in the Immature Male Rat*
George, F. W., Johnson, L. W., & Wilson, J. D. (1989) · Endocrinology · doi:10.1210/endo-125-5-2434 · Cited by 93
Price, P., Wass, J. A. H., Griffin, J. E., Leshin, M., Savage, M. O., Large, D. M., Bu'Lock, D. E., Anderson, D. C., Wilson, J. D., & BESSER, G. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111563 · Cited by 85
Carpenter, T. O., Imperato‐McGinley, J., Boulware, S. D., WEISS, R. M., Shackleton, C. H. L., Griffin, J. E., & Wilson, J. D. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-2-318 · Cited by 84
Self-citation5α-Dihydrotestosterone Formation Is Necessary for Embryogenesis of the Rat Prostate*
George, F. W., & Peterson, K. G. (1988) · Endocrinology · doi:10.1210/endo-122-3-1159 · Cited by 71
The Diagnosis of 5α-Reductase Deficiency in Infancy*
Imperato‐McGinley, J., Gautier, T., Pichardo, M., & Shackleton, C. H. L. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-6-1313 · Cited by 68
Self-citation5 alpha-reductase-2 gene mutations in the Dominican Republic
Cai, L., Zhu, Y., Katz, M. D., Herrera, C., Baez, J. M., Ricart, M. D., Shackleton, C. H. L., & Imperato‐McGinley, J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1730 · Cited by 62
Self-citationKatz, M. D., Cai, L., Zhu, Y., Herrera, C., Ricart, M. D., Shackleton, C. H. L., & Imperato‐McGinley, J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593420 · Cited by 62
Self-citationCai, L., Fratianni, C. M., Gautier, T., & Imperato‐McGinley, J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045956 · Cited by 61
Self-citationFAMILIAL MALE PSEUDOHERMAPHRODITISM DUE TO DEFICIENCY OF 5α‐REDUCTASE
Savage, M. O., Preece, M. A., Jeffcoate, S. L., Ransley, P. G., Rumsby, G., Mansfield, M. D., & Williams, D. I. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb02727.x · Cited by 41
5 alpha-reductase-2 deficiency.
Imperato‐McGinley, J. (1994) · PubMed · Cited by 29
Self-citationThe Syndrome of 5α-Reductase Deficiency
Fratianni, C. M., & Imperato‐McGinley, J. (1994) · The Endocrinologist · doi:10.1097/00019616-199407000-00009 · Cited by 26
Self-citationPotential fertility in incomplete male pseudohermaphroditism type 2.
Cantú, J. M., Hernández-Montes, H., Castillo, V., Sandoval, R., Armendares, S., & Parra, A. R. V. (1976) · PubMed · Cited by 17
Research works printed but not linked: 6
- 10.1210/jc.79.2.409 · DOI
- 10.1210/en.131.3.1149 · DOI
- 10.1210/jc.75.4.1022 · DOI
- Cantu JM, 1976, Rev Invest Clin, 28, 177
- World Health Organization. WHO laboratory manual for the examination of human semen and sperm–cervical mucus interaction. 3rd ed. Cambridge, England: Cambridge University Press, 1992.
- 10.1210/jc.80.11.3160 · DOI
Cited by
Sorted by citations
Steroid 5α-reductase 2 deficiency
Mendonca, B. B., Batista, R. L., Domenice, S., Costa, E. M. F., Arnhold, I. J. P., Russell, D. W., & Wilson, J. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.05.020 · Cited by 548
Androgens and male physiology the syndrome of 5α-reductase-2 deficiency
Imperato‐McGinley, J., & Zhu, Y. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00368-4 · Cited by 313
Self-citationGuidelines for the appropriate use of genetic tests in infertile couples
Foresta, C., Ferlin, A., Gianaroli, L., & Dallapiccola, B. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200805 · Cited by 225
46,XY disorders of sex development (DSD)
Mendonca, B. B., Domenice, S., Arnhold, I. J. P., & Costa, E. M. F. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03392.x · Cited by 209
Intersexuality and Gender Identity Differentiation
Zucker, K. J. (1999) · Annual Review of Sex Research · doi:10.1080/10532528.1999.10559774 · Cited by 161
Metadata
- Authors
- Katz, M. D., Kligman, I., Cai, L.-Q., Zhu, Y.-S., Fratianni, C. M., Zervoudakis, I., Rosenwaks, Z., & Imperato-McGinley, J.
- Affiliations
- Cornell University (US)
- ORCID
- Zhu, Yuan-Shan
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-04-03
- Volume
- 336
- Issue
- 14
- Pages
- 994-998
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2333993541
- Cited by
- 131
- References
- 26
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 16 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 1 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32hl009421-02)
- National Heart, Lung, and Blood Institute (HL-09421-15)
- National Center for Research Resources (M01RR 00047, M01RR000047)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- intrauterine insemination, 46,XY disorders of sex development, dihydrotestosterone, androgen insensitivity syndrome, hypospadias, paternity, male infertility, congenital adrenal hyperplasia
- MeSH terms
- Adult, Female, Humans, Infertility, Male, Insemination, Artificial, Homologous, Isoenzymes, Male, Mutation, Pregnancy, Disorders of Sex Development, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Uterus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
