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Cited by 165

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Insulin Lispro

Holleman, Frits, Hoekstra, Joost B.L.·1997·New England Journal of Medicine

Abstract

The difference in amino acid composition between beef and porcine insulins and human insulin was long thought to be responsible for the immunogenicity of these animal insulins in humans. As a result, much of the effort expended to meet the world's increasing demand for insulin was devoted to the development of synthetic human insulin. However, the introduction of highly purified synthetic human insulin in the early 1980s did not entirely solve the problem of immunogenicity, and the new technology was used instead to change the amino acid structure of human insulin to make it more suitable for subcutaneous administration. This . . .

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Crossref · 10.1056/nejm199707173370307

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Metadata

Authors
Holleman, F., & Hoekstra, J. B. L.
Venue
New England Journal of Medicine
Published
1997-07-17
Volume
337
Issue
3
Pages
176-183
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4237702143
Cited by
165
References
2
FWCI
9.95
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Insulin Lispro. https://app.cochat.ai/papers/10.1056/nejm199707173370307
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Holleman, F., & Hoekstra, J. B. L. (1997). Insulin Lispro. New England Journal of Medicine. https://doi.org/10.1056/nejm199707173370307

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.