Elevated serum thyrotropin in thyroxine-treated patients with hypothyroidism given sertraline
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An increase in TSH associated with sertraline therapy was reported in 11 patients, although another study did not report such an increase.
“An increase in TSH associated with sertraline therapy was reported in 11 patients (186), although another study did not report such an increase (187).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [186]
L-T4 requirements increased in nine L-T4-treated hypothyroid patients under sertraline; in two patients under TSH-suppressive L-T4 therapy, TSH levels rose into the normal range.
“L-T4 requirements increased in nine L-T4-treated hypothyroid patients under sertraline (73). Confirming the sertraline-T4 interaction, in two patients under TSH-suppressive L-T4 therapy, TSH levels rose into the normal range (73).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [73]
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References 3 · Cited by 60
- Authors
- McCowen, K. C., Garber, J. R., & Spark, R.
- ORCID
- Karen Clare McCowen
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-10-02
- Volume
- 337
- Issue
- 14
- Pages
- 1010-1011
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2472349942
- Cited by
- 60
- References
- 3
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2012: 4
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyroid-stimulating hormone, sertraline, hypothyroidism, levothyroxine, selective serotonin reuptake inhibitors, drug-induced hyperthyroidism
- MeSH terms
- Adult, Aged, Drug Interactions, Female, Humans, Hypothyroidism, Male, Middle Aged, Thyrotropin, Thyroxine, 1-Naphthylamine, Sertraline
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