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Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases
Abstract
For more than two decades, the intravenous administration of high doses of IgG pooled from the plasma of healthy donors (immune globulin therapy, also known as “IVIg”) has benefited patients with a variety of autoimmune disorders. Although its mechanism of action is not known, immune globulin is accepted as an effective and convenient alternative to plasmapheresis for treating diseases that are thought to be mediated by pathogenic autoantibodies or immune complexes.1 It is used increasingly to treat neurologic diseases such as inflammatory demyelinating neuropathies, multifocal motor neuropathy, inflammatory myopathies, myasthenia gravis, and the Lambert–Eaton syndrome. The efficacy of immune globulin . . .
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Citations
Cited by
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Roopenian, D. C., & Akilesh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2155 · Cited by 2,346
IgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Pelosof, L. C., & Gerber, D. E. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0099 · Cited by 773
Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies
Keizer, R. J., Huitema, A. D. R., Schellens, J. H. M., & Beijnen, J. H. (2010) · Clinical Pharmacokinetics · doi:10.2165/11531280-000000000-00000 · Cited by 725
Intravenous immunoglobulin for Guillain-Barré syndrome
Hughes, R. A., Swan, A. V., & van Doorn, P. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002063.pub6 · Cited by 721
Metadata
- Authors
- Yu, Z., & Lennon, V. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-01-21
- Volume
- 340
- Issue
- 3
- Pages
- 227-228
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1991027093
- Cited by
- 427
- References
- 0
- FWCI
- 31.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, Z., & Lennon, V. A. (1999). Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases. New England Journal of Medicine. https://doi.org/10.1056/nejm199901213400311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
