Cited by 5,187Blood transfusion and managementTrauma, Hemostasis, Coagulopathy, ResuscitationHemodynamic Monitoring and Therapy

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A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care

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Hébert, Paul C., Wells, George, Blajchman, Morris A., Marshall, John, Martin, Claudio, Pagliarello, Giuseppe, Tweeddale, Martin, Schweitzer, Irwin, Yetisir, Elizabeth·1999·New England Journal of Medicine

DOI 10.1056/nejm199902113400601

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Abstract

BACKGROUND: To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction. METHODS: We enrolled 838 critically ill patients with euvolemia after initial treatment who had hemoglobin concentrations of less than 9.0 g per deciliter within 72 hours after admission to the intensive care unit and randomly assigned 418 patients to a restrictive strategy of transfusion, in which red cells were transfused if the hemoglobin concentration dropped below 7.0 g per deciliter and hemoglobin concentrations were maintained at 7.0 to 9.0 g per deciliter, and 420 patients to a liberal strategy, in which transfusions were given when the hemoglobin concentration fell below 10.0 g per deciliter and hemoglobin concentrations were maintained at 10.0 to 12.0 g per deciliter. RESULTS: Overall, 30-day mortality was similar in the two groups (18.7 percent vs. 23.3 percent, P= 0.11). However, the rates were significantly lower with the restrictive transfusion strategy among patients who were less acutely ill -- those with an Acute Physiology and Chronic Health Evaluation II score of < or =20 (8.7 percent in the restrictive-strategy group and 16.1 percent in the liberal-strategy group; P=0.03) -- and among patients who were less than 55 years of age (5.7 percent and 13.0 percent, respectively; P=0.02), but not among patients with clinically significant cardiac disease (20.5 percent and 22.9 percent, respectively; P=0.69). The mortality rate during hospitalization was significantly lower in the restrictive-strategy group (22.3 percent vs. 28.1 percent, P=0.05). CONCLUSIONS: A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.

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APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients
Gattinoni, L., Brazzi, L., Pelosi, P. P., Latini, R., Tognoni, G., Pesenti, A. M., & Fumagalli, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510193331601 · Cited by 1,486
Effect of anaemia and cardiovascular disease on surgical mortality and morbidity
Carson, J. L., Duff, A., Poses, R. M., Berlin, J. A., Spence, R. K., Trout, R., Noveck, H., & Strom, B. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04330-9 · Cited by 994
A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients
Boyd, O. (1993) · JAMA · doi:10.1001/jama.1993.03510220055034 · Cited by 959
A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease
Vichinsky, E. P., Haberkern, C. M., Neumayr, L., Earles, A. N., Black, D. M., Koshy, M., Pegelow, C. H., Abboud, M. R., Ohene‐Frempong, K., & Iyer, R. V. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330402 · Cited by 644
Beneficial Effects of Leukocyte Depletion of Transfused Blood on Postoperative Complications in Patients Undergoing Cardiac Surgery
van de Watering, L. M. G., Hermans, J., Houbiers, J. G. A., van den Broek, P. J., Bouter, H., Boer, F., Harvey, M. S., Huysmans, H. A., & Brand, A. (1998) · Circulation · doi:10.1161/01.cir.97.6.562 · Cited by 553
RBC transfusion in the ICU. Is there a reason?
Corwin, H., Parsonnet, K. C., & Gettinger, A. (1995) · Chest · doi:10.1378/chest.108.3.767 · Cited by 390
Biologic effects of leukocytes present in transfused cellular blood products
Bordin, J. O., Heddle, N., & Blajchman, M. A. (1994) · Blood · doi:10.1182/blood.v84.6.1703.bloodjournal8461703 · Cited by 357
Self-citation
Does Transfusion Practice Affect Mortality in Critically Ill Patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group
Hébert, P. C., Wells, G. A., Tweeddale, M., Martin, C. M., Marshall, J., Pham, B., Blajchman, M. A., Schweitzer, I., & Pagliarello, G. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.5.9154866 · Cited by 348
Self-citation

Show all 24 references

Research works printed but not linked: 4

Langenfeld JE, 1991, Surgery, 110, 398
Baker CH, 1986, Circ Shock, 20, 127
Friedman LM, Furberg CD, DeMets DL. Fundamentals of clinical trials. 3rd ed. St. Louis: Mosby-Year Book, 1996.
Hebert PC, 1997, Can Med Assoc J, 156, S9

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Spinella, P. C. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817e2ef9 · Cited by 310
Intensive care of the cancer patient: recent achievements and remaining challenges
Azoulay, É., Soares, M., Darmon, M., Benoît, D., Pastores, S. M., & Afessa, B. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-5 · Cited by 315
Acute renal failure in the intensive care unit: A systematic review of the impact of dialytic modality on mortality and renal recovery.
Tonelli, M., Manns, B., & Feller-Kopman, D. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.36318 · Cited by 308
Implementation of an evidence-based “standard operating procedure” and outcome in septic shock*
Kortgen, A., Niederprüm, P., & Bauer, M. W. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000206112.32673.d4 · Cited by 308
A Comparison of the Clinical Impact of Bleeding Measured by Two Different Classifications Among Patients With Acute Coronary Syndromes
Rao, S. V., O’Grady, K., Pieper, K. S., Granger, C. B., Newby, L. K., Mahaffey, K. W., Moliterno, D. J., Lincoff, A. M., Armstrong, P. W., de Werf, F. V., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.060 · Cited by 307
AKI Associated with Cardiac Surgery
Thiele, R. H., Isbell, J. M., & Rosner, M. H. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07830814 · Cited by 311
Biomarkers of sepsis
Marshall, J. C., & Reinhart, K. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a02afc · Cited by 316
Self-citation
Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery
Avidan, M. S., Alcock, E. L., Da Fonseca, J., Ponte, J., Desai, J. B., Despotis, G. J., & Hunt, B. J. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh037 · Cited by 303
Blood use in elective surgery: the Austrian benchmark study
Gombotz, H., Rehak, P., Shander, A., & Hofmann, A. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01286.x · Cited by 299
The next generation in shock resuscitation
Moore, F. A., McKinley, B. A., & Moore, E. E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16415-5 · Cited by 297
Effect of clopidogrel on bleeding after coronary artery bypass surgery
Yende, S. P., & Wunderink, R. G. (2001) · Critical Care Medicine · doi:10.1097/00003246-200112000-00006 · Cited by 294
Coagulopathy and blood component transfusion in trauma
Spahn, D. R., & Rossaint, R. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei169 · Cited by 293
Early Goal-Directed Therapy in Severe Sepsis and Septic Shock Revisited
Otero, R., Nguyen, H. B., Huang, D. T., Gaieski, D. F., Goyal, M. K., Gunnerson, K. J., Trzeciak, S. W., Sherwin, R. L., Holthaus, C. V., Osborn, T. M., et al. (2006) · CHEST Journal · doi:10.1378/chest.130.5.1579 · Cited by 295
Regional citrate versus systemic heparin anticoagulation for continuous renal replacement in critically ill patients
Kutsogiannis, D. J., Gibney, R. T. N., Stollery, D. E., & Gao, J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00342.x · Cited by 290
Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine
Vlaar, A. P. J., Oczkowski, S. J. W., de Bruin, S., Wijnberge, M., Antonelli, M. M., Aubron, C., Ariès, P., Duranteau, J., Juffermans, N. P., Meier, J. M., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05884-8 · Cited by 294
Postinjury multiple organ failure
Dewar, D., Moore, F. A., Moore, E. E., & Balogh, Z. J. (2009) · Injury · doi:10.1016/j.injury.2009.05.024 · Cited by 286
Red blood cell transfusions and nosocomial infections in critically ill patients*
Taylor, R. W., O’Brien, J., Trottier, S. J., Manganaro, L., Cytron, M. A., Lesko, M., Arnzen, K., Cappadoro, C., Fu, M., Plisco, M. S., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000234034.51040.7f · Cited by 286
Perioperative visual loss: what do we know, what can we do?
Roth, S. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep295 · Cited by 284
Evaluation and management of anemia in the elderly
Goodnough, L. T., & Schrier, S. L. (2013) · American Journal of Hematology · doi:10.1002/ajh.23598 · Cited by 281
The Effect of Perioperative Anemia on Clinical and Functional Outcomes in Patients With Hip Fracture
Halm, E. A., WANG, J. J., Boockvar, K. S., Penrod, J. D., Silberzweig, S. B., Magaziner, J. S., Koval, K. J., & Siu, A. L. (2004) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-200407000-00007 · Cited by 276
A Global Definition of Patient Blood Management
Shander, A., Hardy, J., Ozawa, S., Farmer, S. L., Hofmann, A., Frank, S. M., Kor, D. J., Faraoni, D., Freedman, J., & Collaborators (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005873 · Cited by 296
Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes
Rao, S. V., Eikelboom, J. W., Granger, C. B., Harrington, R. A., Califf, R. M., & Bassand, J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm019 · Cited by 273
Anemia in Critical Illness: Insights into Etiology, Consequences, and Management
Hayden, S. J., Albert, T. J., Watkins, T. R., & Swenson, E. R. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201110-1915ci · Cited by 271
Major Femoral Bleeding Complications After Percutaneous Coronary Intervention
Doyle, B. J., Ting, H. H., Bell, M. R., Lennon, R. J., Mathew, V., Singh, M., Holmes, D. R., & Rihal, C. S. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2007.12.006 · Cited by 271
Storage lesion: role of red blood cell breakdown
Kim‐Shapiro, D. B., Lee, J. S., & Gladwin, M. T. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03100.x · Cited by 273
Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants
Franz, A. R., Engel, C., Bassler, D., Rüdiger, M., Thome, U. H., Maier, R. F., Krägeloh‐Mann, I., Kron, M., Essers, J., Bührer, C., et al. (2020) · JAMA · doi:10.1001/jama.2020.10690 · Cited by 275
Anemia, Allogenic Blood Transfusion, and Immunomodulation in the Critically Ill
Raghavan, M., & Marik, P. E. (2005) · CHEST Journal · doi:10.1378/chest.127.1.295 · Cited by 268
The Association of Perioperative Red Blood Cell Transfusions and Decreased Long-Term Survival After Cardiac Surgery
Surgenor, S. D., Kramer, R. S., Olmstead, E. M., Ross, C. S., Sellke, F. W., Likosky, D. S., Marrin, C. A. S., Helm, R. E., Leavitt, B. J., Morton, J. R., et al. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181a2a696 · Cited by 266
Concepts of blood transfusion in adults
Goodnough, L. T., Levy, J. H., & Murphy, M. F. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60650-9 · Cited by 261
Non-variceal upper gastrointestinal haemorrhage: guidelines
(2002) · Gut · doi:10.1136/gut.51.suppl_4.iv1 · Cited by 261
Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta-analysis and Systematic Review
Salpeter, S. R., Buckley, J. S., & Chatterjee, S. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.09.017 · Cited by 261
Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients
Retter, A., Wyncoll, D. L. A., Pearse, R. M., Carson, D., McKechnie, S., Stanworth, S. J., Allard, S., Thomas, D., & Walsh, T. S. (2012) · British Journal of Haematology · doi:10.1111/bjh.12143 · Cited by 264
Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial
Jairath, V., Kahan, B. C., Gray, A. J., Doré, C. J., Mora, A., James, M. W., Stanley, A. J., Everett, S. M., Bailey, A. A., Dallal, H. J., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61999-1 · Cited by 257

Authors: Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E.
Affiliations: University of Ottawa (CA)
McMaster University (CA)
University of Toronto (CA)
Western University (CA)
University of British Columbia (CA)
ORCID: Hébert, Paul C.
Wells, George
Martin, Claudio
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-02-11
Volume: 340
Issue: 6
Pages: 409-417
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199902113400601
OpenAlex: W127034668
Cited by: 5,187
References: 24
Citations by year: 2026: 88 · 2025: 121 · 2024: 123 · 2023: 116 · 2022: 124 · 2021: 137 · 2020: 188 · 2019: 173 · 2018: 168 · 2017: 231 · 2016: 256 · 2015: 246 · 2014: 287 · 2013: 269 · 2012: 254
FWCI: 79.72
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Hamilton Health Sciences
University of Waterloo
Jewish General Hospital
Topics: Health Sciences › Medicine › Hematology › Blood transfusion and management
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords: red blood cell transfusion, restrictive transfusion, liberal transfusion, critically ill patients, hemoglobin threshold, 30-day mortality, organ dysfunction, APACHE II score, age, heart disease, acute myocardial infarction, unstable angina
MeSH terms: Adult, Aged, Critical Care, Female, Hemoglobins, Humans, Intensive Care Units, Male, Middle Aged, Multiple Organ Failure, Logistic Models, Survival Analysis, Critical Illness, Hospital Mortality, Erythrocyte Transfusion, APACHE

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A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care

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