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The Development of Vancomycin Resistance in a Patient with Methicillin-Resistant Staphylococcus aureus Infection
Open accessAbstract
Over the past two decades, vancomycin has been considered the antibiotic of choice for methicillin-resistant Staphylococcus aureus (MRSA) infections. Indeed, multidrug-resistant clones of MRSA for which the only available effective antibacterial agent is vancomycin have recently been identified. Recent reports describing the therapeutic failure of vancomycin for MRSA infections have aroused considerable concern regarding the emergence of MRSA strains for which there will be no effective therapy.1–3 The mechanism of reduced susceptibility in these staphylococcal strains has not been identified, although data indicate that it is not the same as the vancomycin-resistance mechanism in enterococcal strains.4 We describe here . . .
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Citations
Cited by
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Ton-That, H., Liu, G., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12424 · Cited by 567
Mechanisms of vancomycin resistance in Staphylococcus aureus
Gardete, S., & Tomasz, A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci68834 · Cited by 565
Self-citationIncreasing Resistance to Vancomycin and Other Glycopeptides in Staphylococcus aureus
Tenover, F. C., Biddle, J. W., & Lancaster, M. V. (2001) · Emerging Infectious Diseases · doi:10.3201/eid0702.010237 · Cited by 391
Metadata
- Authors
- Sieradzki, K., Roberts, R. B., Haber, S. W., & Tomasz, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-02-18
- Volume
- 340
- Issue
- 7
- Pages
- 517-523
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336324580
- Cited by
- 638
- References
- 0
- FWCI
- 46.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sieradzki, K., Roberts, R. B., Haber, S. W., & Tomasz, A. (1999). The Development of Vancomycin Resistance in a Patient with Methicillin-Resistant Staphylococcus aureus Infection. New England Journal of Medicine. https://doi.org/10.1056/nejm199902183400704
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
